O2-flux-optode for medical application

Gerhard A. Holst; Dietrich W. Luebbers; Edgar I. Voges

doi:10.1117/12.144712

18 May 1993 O2-flux-optode for medical application

Gerhard A. Holst, Dietrich W. Luebbers, Edgar I. Voges

Proceedings Volume 1885, Advances in Fluorescence Sensing Technology; (1993) https://doi.org/10.1117/12.144712
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

About 1-2% of the basal human O₂-consumption is taken up by the skin surface. This amount varies depending on the local skin blood flow. A new sensing device, the O₂-flux- optode, has been developed which should allow the measurement of local O₂-uptake of the skin and thereby indirectly its local circulation. This luminescence-based-sensor (1) is permeable for the analyte O₂, (2) is flexible for covering larger areas of the surface, and (3) does not consume the analyte O₂. The new O₂-flux-optode consists of an indicator layer with an embedded oxygen sensitive fluorescence dye and a test layer with known diffusion properties. If this sensor is applied to the skin, the pO₂ between skin surface and test layer is measured. With defined (or measured) pO₂ of the environment (e.g., air) the O₂-flux (J_O(2)) into the tissue can be determined from the pO₂ gradient ((Delta) pO₂) across the test layer and its material properties (C). This yields to the equation: J_O(2) equals C ^* (Delta) pO₂.

Citation Download Citation

Gerhard A. Holst, Dietrich W. Luebbers, and Edgar I. Voges "O2-flux-optode for medical application", Proc. SPIE 1885, Advances in Fluorescence Sensing Technology, (18 May 1993); https://doi.org/10.1117/12.144712

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