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Proceedings Article

Comprehensive approach to breast cancer detection using light: photon localization by ultrasound modulation and tissue characterization by spectral discrimination

[+] Author Affiliations
Fay A. Marks, Harold W. Tomlinson, Glen W. Brooksby

GE Corporate Research and Development Ctr. (USA)

Proc. SPIE 1888, Photon Migration and Imaging in Random Media and Tissues, 500 (September 14, 1993); doi:10.1117/12.154670
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From Conference Volume 1888

  • Photon Migration and Imaging in Random Media and Tissues
  • Britton Chance; Robert R. Alfano
  • Los Angeles, CA | January 17, 1993

abstract

A new technique called Ultrasound Tagging of Light (UTL) for imaging breast tissue is described. In this approach, photon localization in turbid tissue is achieved by cross- modulating a laser beam with focussed, pulsed ultrasound. Light which passes through the ultrasound focal spot is `tagged' with the frequency of the ultrasound pulse. The experimental system uses an Argon-Ion laser, a single PIN photodetector, and a 1 MHz fixed-focus pulsed ultrasound transducer. The utility of UTL as a photon localization technique in scattering media is examined using tissue phantoms consisting of gelatin and intralipid. In a separate study, in vivo optical reflectance spectrophotometry was performed on human breast tumors implanted intramuscularly and subcutaneously in nineteen nude mice. The validity of applying a quadruple wavelength breast cancer discrimination metric (developed using breast biopsy specimens) to the in vivo condition was tested. A scatter diagram for the in vivo model tumors based on this metric is presented using as the `normal' controls the hands and fingers of volunteers. Tumors at different growth stages were studied; these tumors ranged in size from a few millimeters to two centimeters. It is expected that when coupled with a suitable photon localization technique like UTL, spectral discrimination methods like this one will prove useful in the detection of breast cancer by non-ionizing means.

© (1993) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Fay A. Marks ; Harold W. Tomlinson and Glen W. Brooksby
"Comprehensive approach to breast cancer detection using light: photon localization by ultrasound modulation and tissue characterization by spectral discrimination", Proc. SPIE 1888, Photon Migration and Imaging in Random Media and Tissues, 500 (September 14, 1993); doi:10.1117/12.154670; http://dx.doi.org/10.1117/12.154670


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