Raman spectroscopy in the study of normal and pathological tissue structure and of prosthetic material biocompatibility

Alessandro Bertoluzza; C. Fagnano; A. Tinti; S. Mancini; R. Caramazza; P. G. Marchetti; G. Maggi

doi:10.1117/12.146196

17 June 1993 Raman spectroscopy in the study of normal and pathological tissue structure and of prosthetic material biocompatibility

Alessandro Bertoluzza, C. Fagnano, A. Tinti, S. Mancini, R. Caramazza, P. G. Marchetti, G. Maggi

Author Affiliations +

Proceedings Volume 1922, Laser Study of Macroscopic Biosystems; (1993) https://doi.org/10.1117/12.146196
Event: Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, 1992, Jyvaskyla, Finland

Abstract

Vibrational Raman spectroscopy has proven to be a powerful tool for biomedical applications such as the molecular characterization of normal and pathological tissues as well as the evaluation of prosthetic material bicompatibility. This work deals with the applications of Raman spectroscopy to the study of ocular tissues (lens, cornea, vitreous humour), the respective prosthetic biomaterials, bone tissue, and the main biomaterials used in the prosthetic surgery of bone. In particular the Raman spectra of the cornea in different conditions, of vitreous humour, and of pathological bone are reported and discussed. The Raman spectrum of air dried cornea suggests that the tissue is made up almost entirely of collagen. The spectra of normal and pathological bone tissues indicate that pathological bone has a more minor phosphate content than normal bone and some modifications are also observed for the amide III components. Moreover, the Raman spectrum of an arthroplastic bone before defatting suggests a substitution of phosphate with carbonate ions.

Citation Download Citation

Alessandro Bertoluzza, C. Fagnano, A. Tinti, S. Mancini, R. Caramazza, P. G. Marchetti, and G. Maggi "Raman spectroscopy in the study of normal and pathological tissue structure and of prosthetic material biocompatibility", Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); https://doi.org/10.1117/12.146196

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available