Optical tomography of rat brain

Juergen Beuthan; Richard Freyer; Olaf Minet; Cuong Tran Luu; Uwe Hampel; Rolf-Dieter Naber; Gerhard J. Mueller

doi:10.1117/12.238823

24 April 1996 Optical tomography of rat brain

Juergen Beuthan, Richard Freyer, Olaf Minet, Cuong Tran Luu, Uwe Hampel, Rolf-Dieter Naber, Gerhard J. Mueller

Proceedings Volume 2676, Biomedical Sensing, Imaging, and Tracking Technologies I; (1996) https://doi.org/10.1117/12.238823
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

An experimental set-up for the optical tomography using photon density waves is described. The intensity of a NIR laser diode (825 nm) is modulated with a frequency of 110 MHz (modulating degree equal to 80%). The line scan of a rat brain at 64 linear steps and 64 angular steps contains the ac attenuation and the phase shift separately. Due to the impact of scattering in the medium these data are not the basis for a backprojection and deconvolution for the tomographic reconstruction itself. The first approach for a preprocessing consists in the determination of the geometry dependent modulation transfer function (MTF). The line scan is then corrected by the filter which varies with the position. An optical tomogram of a rat brain is presented. This procedure is suitable for biological objects up to a diameter of 30 mm approximately, for example small finger joints.

Citation Download Citation

Juergen Beuthan, Richard Freyer, Olaf Minet, Cuong Tran Luu, Uwe Hampel, Rolf-Dieter Naber, and Gerhard J. Mueller "Optical tomography of rat brain", Proc. SPIE 2676, Biomedical Sensing, Imaging, and Tracking Technologies I, (24 April 1996); https://doi.org/10.1117/12.238823

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