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Proceedings Article

Internal absorption coefficient and threshold for pulsed laser disruption of melanosomes isolated from retinal pigment epithelium

[+] Author Affiliations
Steven L. Jacques, Jon A. Schwartz

Univ. of Texas M.D. Anderson Cancer Ctr. (USA)

Randolph D. Glickman

Univ. of Texas Health Science Ctr./San Antonio (USA)

Proc. SPIE 2681, Laser-Tissue Interaction VII, 468 (May 7, 1996); doi:10.1117/12.239608
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From Conference Volume 2681

  • Laser-Tissue Interaction VII
  • Steven L. Jacques
  • San Jose, CA | January 27, 1996

abstract

This study determine the threshold radiant exposure from a 10-ns pulsed laser (532 nm) which caused bovine melanosomes to present various observable endpoints of disruption. The endpoints tested were (1) a visible region of clearing in a uniform field of melanosomes under a glass cover slip, (2) an audible sound, and (3) the increase in melanin photoreactivity due to photodisruption of melanosomes. The thresholds were tested for different starting temperatures by pre-equilibrating the melanosomes in aqueous solution at various temperatures. Lower temperatures required larger exposures to attain a given endpoint. The data suggest that bovine RPE melanosomes are about 4-fold denser in melanin content than cutaneous melanosomes.

© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Steven L. Jacques ; Randolph D. Glickman and Jon A. Schwartz
"Internal absorption coefficient and threshold for pulsed laser disruption of melanosomes isolated from retinal pigment epithelium", Proc. SPIE 2681, Laser-Tissue Interaction VII, 468 (May 7, 1996); doi:10.1117/12.239608; http://dx.doi.org/10.1117/12.239608


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