Ultrasound-guided interventional PDT of liver cancer

Chaoying Zeng; Dong Yang; Ping Huang; Huijuan Zhang; Muyin Huang; Ji Chen; Guorong Lu

doi:10.1117/12.251938

23 September 1996 Ultrasound-guided interventional PDT of liver cancer

Chaoying Zeng, Dong Yang, Ping Huang, Huijuan Zhang, Muyin Huang, Ji Chen, Guorong Lu

Proceedings Volume 2887, Lasers in Medicine and Dentistry: Diagnostics and Treatment; (1996) https://doi.org/10.1117/12.251938
Event: Photonics China '96, 1996, Beijing, China

Abstract

Thirty patients with advanced liver cancer were treated by interstitial photodynamic therapy (PDT). These included 28 hepatocellular carcinoma and two adenocarcinoma, 19 primary tumors and 11 recurred follow other treatments. The diameter of tumors were 7-10cm in 13 cases and 10-16cm in 17 cases. In this study, an argon laser pumped dye laser system was used to give a CW laser beam at 630 nm which was split and coupled into there optical fibers. The patients were injected intravenously with photosensitizer hematoporphyrin derivative at a dose of 5mg/kg body weight 48 hours before PDT. Then the fibers were inserted into tumor by ultrasound- guided percutaneous puncture. The inserted irradiation points were spaced in entire tumor with the light release power 300mW and the irradiation time 12 minutes per point. Total 52 treatments were performed in 30 patients. Among them, 14 cases were treated only one time and 16 cases via 2-3 times. The follow-up was carried out in 25 cases for 12- 24 months. The results show that significant remission was 22 percent in those patients by only one treatment and 62 percent in those via 2 to 3 treatments. The shrink rate of tumor size was over 90 percent in five of six cases after treatment 3. The survival time has been over one year in 12 cases. No obvious change to be found for all patients in liver function test, renal function test and blood routine examination. The level of AFP indicated a descending trend after PDT. This work indicate that PDT is effective and safe for the treatment of large liver cancers including those recurred follow hepatic resection and those failed in hepatic artery infusion embolic chemotherapy.

Citation Download Citation

Chaoying Zeng, Dong Yang, Ping Huang, Huijuan Zhang, Muyin Huang, Ji Chen, and Guorong Lu "Ultrasound-guided interventional PDT of liver cancer", Proc. SPIE 2887, Lasers in Medicine and Dentistry: Diagnostics and Treatment, (23 September 1996); https://doi.org/10.1117/12.251938

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