Specific labeling of microtumors in the hen's egg test system by dimethoxyhematoporphyrin

Anja Vervoorts; Joerg G. Moser; Gelii V. Ponomarev; H. Achim Rood

doi:10.1117/12.260791

4 December 1996 Specific labeling of microtumors in the hen's egg test system by dimethoxyhematoporphyrin

Anja Vervoorts, Joerg G. Moser, Gelii V. Ponomarev, H. Achim Rood

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260791
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

The accumulation of fluorescent dyes and anticancer drugs in tumors is a fundamental requirement for tumor-diagnosis and therapy. We tested various photosensitizers on vascularized microtumors in the hen's egg test system according to their distribution and accumulation by in-situ videofluorescence microscopy and their influence on tumor blood flow by laser- Doppler spectroscopy. Only 2,4-di((alpha) -methoxyethyl)- hematoporphyrin showed strict tumor localization while diglucosamidyl-heptyl-chlorin labeled cell membranes exclusively. Results from laser-Doppler spectroscopy did not show any influence on tumor blood flow. Intelligent combining of the properties of these sensitizers with accumulation strategies should show in principle strict tumor localization without targeting of non-tumor tissues.

Citation Download Citation

Anja Vervoorts, Joerg G. Moser, Gelii V. Ponomarev, and H. Achim Rood "Specific labeling of microtumors in the hen's egg test system by dimethoxyhematoporphyrin", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260791

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