CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 2970 > Article
Paper
22 May 1997 Influence of hepatic perfusion and application mode in an animal experimental study on laser-induced thermotherapy (LITT) in the liver
Dirk Albrecht, Christoph-Thomas Germer, Christoph Martin Isbert, Andre Roggan, Heinz-Johannes Buhr
Author Affiliations +
Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275018
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States
Abstract
The aim of the present animal experimental study was to investigate the effect of temporarily interrupting hepatic perfusion as well as the application mode on inducible coagulation volumes. Experiments were carried out using a Nd:YAG-laser at a wavelength of 1064 nm. A special multifiber optical component was used. Ten German hybrid pigs served as the experimental animals. All animals were sacrificed four hours after the end of application, and the livers were removed for histological examination. With a single application, a mean lesion volume of 2503 mm3 resulted from a total applied energy of 4356 J. Under temporary occlusion of hepatic circulation a lesion volume of 7452 mm3 was found (p less than 0.01). Multifiber laser application with hepatic circulation led to a mean volume of 14612 mm3. During interrupted circulation, overlapping tissue lesions with a mean volume of 50285 mm3 were induced (p less than 0.01). Microscopic examination showed that the rim seen macroscopically was identical. As well the application mode as the hepatic circulation are statistically significant parameters for the inducible lesion volumes. The interruption of the liver perfusion during laser application led to a significant increase of the hyperthermically induced tissue lesion for single- and multifiber applications.
© (1997) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Dirk Albrecht, Christoph-Thomas Germer, Christoph Martin Isbert, Andre Roggan, and Heinz-Johannes Buhr "Influence of hepatic perfusion and application mode in an animal experimental study on laser-induced thermotherapy (LITT) in the liver", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275018
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 6 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Liver
Heat therapy
Laser applications
Light emitting diodes
Laser tissue interaction
Optical components
Tissues
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top