Three-dimensional tomographic reconstruction of simulated and in-vivo subsurface chromophores

Derek J. Smithies; Thomas E. Milner; J. Stuart Nelson M.D.; Martin J. C. van Gemert; Dennis M. Goodman

doi:10.1117/12.275475

16 June 1997 Three-dimensional tomographic reconstruction of simulated and in-vivo subsurface chromophores

Derek J. Smithies, Thomas E. Milner, J. Stuart Nelson M.D., Martin J. C. van Gemert, Dennis M. Goodman

Proceedings Volume 2975, Laser-Tissue Interaction VIII; (1997) https://doi.org/10.1117/12.275475
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

IR tomography (IRT) is a non-contact technique to determine the size and position of sub-surface and position of sub- surface chromophores, using a recorded time sequence of IR emission images following pulsed laser irradiation. A potential application for IRT is the laser treatment of port wine stains (PWS), where the clinician needs diagnostic information to select optical irradiation parameters. In this paper, we report recent progress using IRT to determine diagnostic information regarding blood vessels comprising a PWS. In our simulations, a 3D skin model containing an epidermis and blood vessels is used, from which a time sequence of IR emission images is calculated. Size and position of sub-surface chromophores computed from the time sequence of IR emission images by application of an inversion algorithm are very close to actual values. For in vivo studies, the chick chorioallantoic membrane is an ideal PWS mode. Size and position of a sub-surface blood vessel are correctly predicted by application of an inversion algorithm, given a recorded time sequence of IR emission images.

Citation Download Citation

Derek J. Smithies, Thomas E. Milner, J. Stuart Nelson M.D., Martin J. C. van Gemert, and Dennis M. Goodman "Three-dimensional tomographic reconstruction of simulated and in-vivo subsurface chromophores", Proc. SPIE 2975, Laser-Tissue Interaction VIII, (16 June 1997); https://doi.org/10.1117/12.275475

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