Use of time-dependent contrast functions to discriminate between the scattering and absorption properties of abnormal regions hidden within a tissue-like phantom

Amir H. Gandjbakhche; Victor V. Chernomordik; Robert F. Bonner; Jeremy C. Hebden; Ralph J. Nossal

doi:10.1117/12.280246

18 August 1997 Use of time-dependent contrast functions to discriminate between the scattering and absorption properties of abnormal regions hidden within a tissue-like phantom

Amir H. Gandjbakhche, Victor V. Chernomordik, Robert F. Bonner, Jeremy C. Hebden, Ralph J. Nossal

Author Affiliations +

Proceedings Volume 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II; (1997) https://doi.org/10.1117/12.280246
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

The success of time-resolved imaging of an abnormal site embedded in thick tissue may rely on one's ability to quantify the absorption coefficient of the target as a specific spectroscopic signature. This task is particularly complicated when the scattering properties of the target differ from those of the surrounding tissue. Using data obtained from time- resolved transillumination experiments of abnormally absorbing and differentially scattering objects embedded in a tissue- like phantom, we show how a new deconvolution algorithm enables us to quantify the optical properties of the target. The algorithm is based on a photon random walk theory that expresses different time-dependent point spread functions to calculate the diffusive and absorptive contrasts obtained in time-of-flight measurements.

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Amir H. Gandjbakhche, Victor V. Chernomordik, Robert F. Bonner, Jeremy C. Hebden, and Ralph J. Nossal "Use of time-dependent contrast functions to discriminate between the scattering and absorption properties of abnormal regions hidden within a tissue-like phantom", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); https://doi.org/10.1117/12.280246

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