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Proceedings Article

Use of time-dependent contrast functions to discriminate between the scattering and absorption properties of abnormal regions hidden within a tissue-like phantom

[+] Author Affiliations
Amir H. Gandjbakhche, Victor V. Chernomordik

National Institutes of Health (Israel)

Robert F. Bonner, Ralph J. Nossal

National Institutes of Health (USA)

Jeremy C. Hebden

Univ. College London (United Kingdom)

Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, 211 (August 18, 1997); doi:10.1117/12.280246
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From Conference Volume 2979

  • Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
  • Britton Chance; Robert R. Alfano
  • San Jose, CA, USA | February 08, 1997

abstract

The success of time-resolved imaging of an abnormal site embedded in thick tissue may rely on one's ability to quantify the absorption coefficient of the target as a specific spectroscopic signature. This task is particularly complicated when the scattering properties of the target differ from those of the surrounding tissue. Using data obtained from time- resolved transillumination experiments of abnormally absorbing and differentially scattering objects embedded in a tissue- like phantom, we show how a new deconvolution algorithm enables us to quantify the optical properties of the target. The algorithm is based on a photon random walk theory that expresses different time-dependent point spread functions to calculate the diffusive and absorptive contrasts obtained in time-of-flight measurements.

© (1997) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Amir H. Gandjbakhche ; Victor V. Chernomordik ; Robert F. Bonner ; Jeremy C. Hebden and Ralph J. Nossal
"Use of time-dependent contrast functions to discriminate between the scattering and absorption properties of abnormal regions hidden within a tissue-like phantom", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, 211 (August 18, 1997); doi:10.1117/12.280246; http://dx.doi.org/10.1117/12.280246


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