Dynamic light-scattering study of gelatin and aggregation of gastric mucin

Rama Bansil; Xingxiang Cao; K. Ramakrishnan Bhaskar; Jeffrey Thomas LaMont M.D.

doi:10.1117/12.273605

2 May 1997 Dynamic light-scattering study of gelatin and aggregation of gastric mucin

Rama Bansil, Xingxiang Cao, K. Ramakrishnan Bhaskar, Jeffrey Thomas LaMont M.D.

Proceedings Volume 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology; (1997) https://doi.org/10.1117/12.273605
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Dynamic light scattering studies show that concentration and pH play important roles in determining pig gastric mucin's (PGM) ability to aggregate and gel. At low concentrations, PGM macromolecules exist in solution predominantly in the form of monomers. At high concentrations, PGM macromolecules aggregate to form supra-macromolecular clusters. When the pH of the high concentration PGM solution is changed from 7.0 to 2.0, the system undergoes a sol-gel transition: from a solution of polydisperse aggregates to a gel. This pH and concentration dependent sol-gel transition of PGM solution may provide a mechanism for the mammalian stomach to protect itself against being digested by the gastric juice.

Citation Download Citation

Rama Bansil, Xingxiang Cao, K. Ramakrishnan Bhaskar, and Jeffrey Thomas LaMont M.D. "Dynamic light-scattering study of gelatin and aggregation of gastric mucin", Proc. SPIE 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology, (2 May 1997); https://doi.org/10.1117/12.273605

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