Layered polymer: inorganic composite waveguides for biosensor applications

Jussi Hiltunen; Meng Wang; Christina Liedert; Sanna Aikio; Noriyuki Masuda; Stuart Pearce; Martin Charlton; Pentti Karioja

doi:10.1117/12.922267

8 May 2012 Layered polymer: inorganic composite waveguides for biosensor applications

Jussi Hiltunen, Meng Wang, Christina Liedert, Sanna Aikio, Noriyuki Masuda, Stuart Pearce, Martin Charlton, Pentti Karioja

Author Affiliations +

Proceedings Volume 8427, Biophotonics: Photonic Solutions for Better Health Care III; 84270I (2012) https://doi.org/10.1117/12.922267
Event: SPIE Photonics Europe, 2012, Brussels, Belgium

Abstract

In this work, we investigate the usability of layered polymer - inorganic composite waveguides for label-free sensing of surface bound bioreactions in an aqueous environment. The waveguide structure consists of a nanoimprint fabricated polymeric inverted rib waveguide with a sputtered Ta₂O₅ thin film on top. The interaction of the optical field with the surface is increased as a consequence of the mode profile localization near the surface, when high-index coating is deposited on a low-index waveguide. Young interferometer configuration with reference and sensors waveguide arms was utilized in sensor chips. Light from a laser source was end-fire coupled into the chips and interference pattern produced by the outcoupled light was investigated. External μ-fluidic pump was used to produce the analyte flow. Ambient refractive index change was characterized by applying DI-water with varying glucose concentration on waveguides. With the waveguide length of 1 cm a detection limit in the order of 10^-7 - 10^-6 refractive index unit (RIU) was achieved. Specific binding reactions on the surface were investigated with C - reactive protein (CRP) antibodies and antigens.

Citation Download Citation

Jussi Hiltunen, Meng Wang, Christina Liedert, Sanna Aikio, Noriyuki Masuda, Stuart Pearce, Martin Charlton, and Pentti Karioja "Layered polymer: inorganic composite waveguides for biosensor applications", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84270I (8 May 2012); https://doi.org/10.1117/12.922267

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Waveguides

Refractive index

Polymers

Polymer multimode waveguides

Coating

Sensors

Interferometers

Show All Keywords

Keywords/Phrases

Search In:

Publication Years