An optical biosensor using MEMS-based V-grooves

Ye Tian; Xiaodong Ma; Xiaotian Zou; Nan Wu; Xingwei Wang

doi:10.1117/12.880585

26 May 2011 An optical biosensor using MEMS-based V-grooves

Ye Tian, Xiaodong Ma, Xiaotian Zou, Nan Wu, Xingwei Wang

Proceedings Volume 8024, Advanced Environmental, Chemical, and Biological Sensing Technologies VIII; 802403 (2011) https://doi.org/10.1117/12.880585
Event: SPIE Defense, Security, and Sensing, 2011, Orlando, Florida, United States

Abstract

An optical fiber biosensor featuring miniaturization, electromagnetic interference (EMI)-immunity, and flexibility is presented. The sensor was fabricated by aligning two gold-deposited optical single-mode fiber facets inside V-grooves on a silicon chip to form a Fabry-Perot (FP) cavity. The mirrors on the fiber facets were made of deposited gold (Au) films, which provided a high finesse to produce a highly sensitivity. Microelectromechanical systems (MEMS) fabrication techniques were used to precisely control the profile and angle of the V-grooves on the silicon. The biotin-terminated thiol molecule was firstly immobilized on the gold surface. Subsequently, the molecules of Neutravidin were specifically bound to the biotin-terminated self-assembled monolayers (SAMs). The induced changes of cavity length and refractive index (RI) upon the gold surface lead to an optical path difference (OPD) of the FP cavity, which was detected by demodulating the transmission spectrum phase shift. By taking advantage of MEMS techniques, multiple biosensors can be integrated into one small silicon chip for detecting various biomolecule targets simultaneously.

Citation Download Citation

Ye Tian, Xiaodong Ma, Xiaotian Zou, Nan Wu, and Xingwei Wang "An optical biosensor using MEMS-based V-grooves", Proc. SPIE 8024, Advanced Environmental, Chemical, and Biological Sensing Technologies VIII, 802403 (26 May 2011); https://doi.org/10.1117/12.880585

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