Devising an endoluminal bimodal probe which combines autofluorescence and reflectance spectroscopy with high resolution MRI for early stage colorectal cancer diagnosis: technique, feasibility and preliminary in-vivo (rabbit) results

A. Ramgolam; R. Sablong; B. Bou-Saïd; S. Bouvard; H. Saint-Jalmes; O. Beuf

doi:10.1117/12.889602

8 June 2011 Devising an endoluminal bimodal probe which combines autofluorescence and reflectance spectroscopy with high resolution MRI for early stage colorectal cancer diagnosis: technique, feasibility and preliminary in-vivo (rabbit) results

A. Ramgolam, R. Sablong, B. Bou-Saïd, S. Bouvard, H. Saint-Jalmes, O. Beuf

Author Affiliations +

Proceedings Volume 8087, Clinical and Biomedical Spectroscopy and Imaging II; 80870O (2011) https://doi.org/10.1117/12.889602
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

Conventional white light endoscopy (WLE) is the most widespread technique used today for colorectal cancer diagnosis and is considered as the gold standard when coupled to biopsy and histology. However for early stage colorectal cancer diagnosis, which is very often characterised by flat adenomas, the use of WLE is quite difficult due to subtle or quasiinvisible morphological changes of the colonic lining. Figures worldwide point out that diagnosing colorectal cancer in its early stages would significantly reduce the death toll all while increasing the 5-year survival rate. Several techniques are currently being investigated in the scope of providing new tools that would allow such a diagnostic or assist actual techniques in so doing. We hereby present a novel technique where High spatial Resolution MRI (HR-MRI) is coupled to optical spectroscopy (autofluorescence and reflectance) in a bimodal endoluminal probe to extract morphological data and biochemical information respectively. The design and conception of the endoluminal probe along with the preliminary results obtained with an organic phantom and in-vivo (rabbit) are presented and discussed.

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A. Ramgolam, R. Sablong, B. Bou-Saïd, S. Bouvard, H. Saint-Jalmes, and O. Beuf "Devising an endoluminal bimodal probe which combines autofluorescence and reflectance spectroscopy with high resolution MRI for early stage colorectal cancer diagnosis: technique, feasibility and preliminary in-vivo (rabbit) results", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80870O (8 June 2011); https://doi.org/10.1117/12.889602

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