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Proceedings Article

Development of a multi-view multi-spectral bioluminescence tomography small animal imaging system

[+] Author Affiliations
James A. Guggenheim, Hamid Dehghani, Hector Basevi, Iain B. Styles, Jon Frampton

The Univ. of Birmingham (United Kingdom)

Proc. SPIE 8088, Diffuse Optical Imaging III, 80881K (June 14, 2011); doi:10.1117/12.889863
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From Conference Volume 8088

  • Diffuse Optical Imaging III
  • Andreas H. Hielscher; Paola Taroni
  • Munich, Germany | May 22, 2011

abstract

Steps are presented towards the development of a new bioluminescence tomography (BLT) imaging system for in vivo small animal studies. A 2-mirror-based multi-view data collection scheme is investigated in conjunction with multi-spectral imaging, leading to the production of 3D volumetric maps of molecular source distributions in simulation and in physical phantom studies by way of a finite element model (FEM) based reconstruction method. A proof of concept is subsequently demonstrated showing a full work flow from data acquisition to 3D reconstruction. Results suggest that the multi-view mirror-based approach represents a strong improvement over standard single-view methods, with improvements of up to 58% in source localisation accuracy being observed for deep sources.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

James A. Guggenheim ; Hamid Dehghani ; Hector Basevi ; Iain B. Styles and Jon Frampton
"Development of a multi-view multi-spectral bioluminescence tomography small animal imaging system", Proc. SPIE 8088, Diffuse Optical Imaging III, 80881K (June 14, 2011); doi:10.1117/12.889863; http://dx.doi.org/10.1117/12.889863


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