Effect of gold nanoparticles in the local heating of skin tumors induced by phototherapy

I. Salas-García; F. Fanjul-Vélez; N. Ortega-Quijano; A. Lavín-Castanedo; P. Mingo-Ortega; M. López-Escobar; J. L. Arce-Diego

doi:10.1117/12.889830

2 June 2011 Effect of gold nanoparticles in the local heating of skin tumors induced by phototherapy

I. Salas-García, F. Fanjul-Vélez, N. Ortega-Quijano, A. Lavín-Castanedo, P. Mingo-Ortega, M. López-Escobar, J. L. Arce-Diego

Author Affiliations +

Proceedings Volume 8092, Medical Laser Applications and Laser-Tissue Interactions V; 809204 (2011) https://doi.org/10.1117/12.889830
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

During optical therapies, several types of interaction between the optical radiation and the target tissue can occur. The application of different power densities and the variation of the exposure time can cause from photochemical reactions to photodisruption. Photothermal therapy (PTT) is based in the thermal interactions, where the biological injury is provoked by a given increase of their temperature during the exposition to the optical source. Another treatment option very extended in several clinical fields due to its promising results is Photodynamic Therapy. This treatment modality is based in photochemical reactions where it is also required oxygen and the administration of a photosensitive substance known as photosensitizer. The use of nanotechnology in optical therapeutic techniques, constitutes a novel promising treatment strategy. Specifically, gold nanoparticles can improve different issues related to the transport of photosensitizers or the light energy absorption and the subsequent heat generation. This work focuses in the effects that can produce the use of gold nanoparticles in Photothermal and Photodynamic Therapies applied to skin diseases commonly treated by means of these techniques. We present a thermal model that permits to calculate the temperature distribution in different kinds of pathological dermatological tissues depending on the optical power provided by the optical source. The results obtained permit to compare the thermal injury produced depending on not only the provided power but also the type of pathology and the incorporation or not of gold nanoparticles in the target tissue.

Citation Download Citation

I. Salas-García, F. Fanjul-Vélez, N. Ortega-Quijano, A. Lavín-Castanedo, P. Mingo-Ortega, M. López-Escobar, and J. L. Arce-Diego "Effect of gold nanoparticles in the local heating of skin tumors induced by phototherapy", Proc. SPIE 8092, Medical Laser Applications and Laser-Tissue Interactions V, 809204 (2 June 2011); https://doi.org/10.1117/12.889830

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available