OCT visualization of mucosal radiation damage in patients with head and neck cancer: pilot study

Natalia Gladkova M.D.; Anna Maslennikova; Irina Balalaeva; Yulia Vyseltseva; Natalia Kornoukhova; Roman Larin; Anna Terentieva; Nina Khomutinnikova; Yulia Fomina; Vladislav Kamensky; Grigory Gelikonov; Felix Feldchtein

doi:10.1117/12.647601

22 February 2006 OCT visualization of mucosal radiation damage in patients with head and neck cancer: pilot study

Natalia Gladkova M.D., Anna Maslennikova, Irina Balalaeva, Yulia Vyseltseva, Natalia Kornoukhova, Roman Larin, Anna Terentieva, Nina Khomutinnikova, Yulia Fomina, Vladislav Kamensky, Grigory Gelikonov, Felix Feldchtein

Author Affiliations +

Proceedings Volume 6078, Photonic Therapeutics and Diagnostics II; 60781J (2006) https://doi.org/10.1117/12.647601
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

We present the results in optical coherence tomography (OCT) visualization of structural changes in human oral cavity and pharyngeal mucosa for 14 patients in the process of radiation and chemoradiation therapy. Typical mucosal changes are seen as a decrease in the tissue layer contrast progressing to a complete contrast loss as severe mucosal damage occurs. Similar evolution in OCT images was observed for all patients. OCT changes can be seen prior to visual mucosal changes and increased as more mucosal damage occurs. Moreover, OCT was able to obtain information on the specific features of the patient response depending on the irradiation method and the individual radiosensitivity.

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Natalia Gladkova M.D., Anna Maslennikova, Irina Balalaeva, Yulia Vyseltseva, Natalia Kornoukhova, Roman Larin, Anna Terentieva, Nina Khomutinnikova, Yulia Fomina, Vladislav Kamensky, Grigory Gelikonov, and Felix Feldchtein "OCT visualization of mucosal radiation damage in patients with head and neck cancer: pilot study", Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60781J (22 February 2006); https://doi.org/10.1117/12.647601

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