Multimode spectroscopy for the in vivo assessment of post-inflammatory pigmentation: preliminary observations

Jianhua Zhao; Hana Alkhayat; Ahmad Al Robaee; Haishan Zeng; David I. McLean; Harvey Lui

doi:10.1117/12.650200

22 February 2006 Multimode spectroscopy for the in vivo assessment of post-inflammatory pigmentation: preliminary observations

Jianhua Zhao, Hana Alkhayat, Ahmad Al Robaee, Haishan Zeng, David I. McLean, Harvey Lui

Author Affiliations +

Proceedings Volume 6078, Photonic Therapeutics and Diagnostics II; 607809 (2006) https://doi.org/10.1117/12.650200
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Although post-inflammatory pigmentation (PIH) is a common acquired skin disorder, however, its mechanism still remains unclear. In this paper, multimode optical spectroscopic techniques including diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy have been used to probe the morphologic and biochemical changes associated with PIH. Both pigmented skin and the adjacent normal skin were measured for paired analysis. Distinctive spectral features were observed which may provide the potentials for identifying the mechanism of PIH. The diffuse reflectance spectrum was also converted into the CIE standard L*a*b* color system. The melanin and the hemoglobin content in the PIH were quantitatively derived from the diffusive reflectance spectrum using the Stamatas-Kollias algorithm. It was found that PIH always has a lower value in L* and more melanin and hemoglobin content which is consistent with clinical appearance of dark skin as perceived by the human eye.

Citation Download Citation

Jianhua Zhao, Hana Alkhayat, Ahmad Al Robaee, Haishan Zeng, David I. McLean, and Harvey Lui "Multimode spectroscopy for the in vivo assessment of post-inflammatory pigmentation: preliminary observations", Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 607809 (22 February 2006); https://doi.org/10.1117/12.650200

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available