Cytotoxical products formation on the nanoparticles heated by the pulsed laser radiation

Boris Ya. Kogan; Andrey A. Titov; Victor Yu. Rakitin; Larisa D. Kvacheva; Sergey G. Kuzmin; Georgy N. Vorozhtsov

doi:10.1117/12.658131

28 February 2006 Cytotoxical products formation on the nanoparticles heated by the pulsed laser radiation

Boris Ya. Kogan, Andrey A. Titov, Victor Yu. Rakitin, Larisa D. Kvacheva, Sergey G. Kuzmin, Georgy N. Vorozhtsov

Proceedings Volume 6095, Nanobiophotonics and Biomedical Applications III; 60950S (2006) https://doi.org/10.1117/12.658131
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Cytotoxical effect of a pulsed laser irradiation in presence of nanoparticles of carbon black, sulphuretted carbon and fullerene-60 on death of human uterus nick cancer HeLa and mice lymphoma P 388 cells was studied in vitro. Bubbles formation as result of "microexplosions" of nanoparticles is one of possible mechanisms of this effect. Other possible mechanism is cytotoxical products formation in result of pyrolysis of nanoparticles and biomaterial which is adjoining. The cytotoxical effect of addition of a supernatant from the carbon nanoparticles suspensions irradiated by the pulsed laser was studied to test this assumption. Analysis using gas chromatograph determined that carbon monoxide is principal gaseous product of such laser pyrolysis. This is known as cytotoxical product. Efficiency of its formation is estimated.

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Boris Ya. Kogan, Andrey A. Titov, Victor Yu. Rakitin, Larisa D. Kvacheva, Sergey G. Kuzmin, and Georgy N. Vorozhtsov "Cytotoxical products formation on the nanoparticles heated by the pulsed laser radiation", Proc. SPIE 6095, Nanobiophotonics and Biomedical Applications III, 60950S (28 February 2006); https://doi.org/10.1117/12.658131

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