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Proceedings Article

Diffuse reflectance spectral imaging for breast tumor margin assessment

[+] Author Affiliations
Justin Y. Lo, Sulochana Dhar, Bing Yu, Martin A. Brooke, Nan M. Jokerst, Nimmi Ramanujam

Duke Univ. (USA)

Thomas F. Kuech

Univ. of Wisconsin-Madison (USA)

Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 821407 (February 9, 2012); doi:10.1117/12.909259
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From Conference Volume 8214

  • Advanced Biomedical and Clinical Diagnostic Systems X
  • Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren Grundfest
  • San Francisco, California, USA | January 21, 2012

abstract

Diffuse reflectance spectroscopy has been previously explored as a promising method for providing real-time visual maps of tissue composition to help surgeons determine breast lumpectomy margins and to ensure the complete removal of a tumor during surgery. We present the simple design, validation, and implementation of a compact and cost-effective spectral imaging system for the application of tumor margin assessment. Our new system consists of a broadband source with bandpass filters for illumination and a fabricated custom 16-pixel photodiode imaging array for the detection of diffuse reflectance. The system prototype was characterized in tissue-mimicking phantoms and has an SNR of greater than 40 dB in phantoms, animals, and human tissue. We show proof-of-concept for performing fast, wide-field spectral imaging with a simple, inexpensive design. The strategy also allows for the scaling to higher pixel number and density in future iterations of the system.

© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Justin Y. Lo ; Sulochana Dhar ; Bing Yu ; Martin A. Brooke ; Thomas F. Kuech, et al.
"Diffuse reflectance spectral imaging for breast tumor margin assessment", Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 821407 (February 9, 2012); doi:10.1117/12.909259; http://dx.doi.org/10.1117/12.909259


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