Ultrafast time-dependent fluorescence spectroscopy for human breast cancer detection

Yang Pu; Guichen Tang; B. B. Das; C.-H. Liu; Asima Pradhan; Robert R. Alfano

doi:10.1117/12.906254

31 January 2012 Ultrafast time-dependent fluorescence spectroscopy for human breast cancer detection

Yang Pu, Guichen Tang, B. B. Das, C.-H. Liu, Asima Pradhan, Robert R. Alfano

Proceedings Volume 8220, Optical Biopsy X; 82200X (2012) https://doi.org/10.1117/12.906254
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Time-resolved fluorescence emission from normal breast tissue, benign and malignant breast tumors were measured using excitation of 100 fs pulses at 310nm. Fluorescence relaxation decay parameters were extracted from the measured temporal emission profiles. The decay times and amplitudes of fast and slow profiles of malignant tissues were different from normal and benign tissues, which allows the malignant tumor to be separated from non-malignant breast tissue. The differences between the decay times of slow and fast component can be explained by tissue structure changes during breast cancer evolution.

Citation Download Citation

Yang Pu, Guichen Tang, B. B. Das, C.-H. Liu, Asima Pradhan, and Robert R. Alfano "Ultrafast time-dependent fluorescence spectroscopy for human breast cancer detection", Proc. SPIE 8220, Optical Biopsy X, 82200X (31 January 2012); https://doi.org/10.1117/12.906254

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KEYWORDS

Tissues

Breast

Tumors

Luminescence

Time resolved spectroscopy

Picosecond phenomena

Fluorescence spectroscopy

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