Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

In vivo photoacoustic imaging of tyrosinase expressing tumours in mice

[+] Author Affiliations
Jan Laufer, Amit Jathoul, Peter Johnson, Edward Zhang, Mark Lythgoe, R. Barbara Pedley, Martin Pule, Paul Beard

Univ. College London (United Kingdom)

Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230M (February 9, 2012); doi:10.1117/12.907006
Text Size: A A A
From Conference Volume 8223

  • Photons Plus Ultrasound: Imaging and Sensing 2012
  • Alexander A. Oraevsky; Lihong V. Wang
  • San Francisco, California, USA | January 21, 2012

abstract

Two human tumour cell lines (K562, 293T) were stably transfected to achieve the genetic expression of tyrosinase, which is involved in the production of the pigment eumelanin. The cells were injected subcutaneously into nude mice to form tumour xenografts, which were imaged over a period of up to 26 days using an all-optical photoacoustic imaging system. 3D photoacoustic images of the tumours and the surrounding vasculature were acquired at excitation wavelengths ranging from 600nm to 770nm. The images showed tumour growth and continued tyrosinase expression over the full 26 day duration of the study. These findings were confirmed by histological analysis of excised tumour samples.

© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Jan Laufer ; Amit Jathoul ; Peter Johnson ; Edward Zhang ; Mark Lythgoe, et al.
"In vivo photoacoustic imaging of tyrosinase expressing tumours in mice", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230M (February 9, 2012); doi:10.1117/12.907006; http://dx.doi.org/10.1117/12.907006


Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.