Study of light fluence rate distribution in photodynamic therapy using finite-element method

Jun Li; Timothy C. Zhu; Jarod C. Finlay

doi:10.1117/12.646251

6 March 2006 Study of light fluence rate distribution in photodynamic therapy using finite-element method

Jun Li, Timothy C. Zhu, Jarod C. Finlay

Proceedings Volume 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV; 61390M (2006) https://doi.org/10.1117/12.646251
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

In photodynamic therapy (PDT), it is desirable to determine the light fluence distribution accurately for treatment planning. Earlier studies have shown heterogeneous distribution of optical properties in patients' prostates. Finite-element method (FEM) is suitable for dealing with heterogeneous media and irregular geometries. Cylindrical diffusing fibers (CDFs) were modeled as linear sources of finite lengths, using the same parameters as those used in the treatments. Meshes were generated in the three-dimensional (3D) prostate geometry, reconstructed using transrectal ultrasound images of the prostate. Heterogeneous optical properties measured in the prostate were applied in the calculation and the refractive-index mismatch boundary condition was studied. Compared with the measurements, the FEM calculations using heterogeneous optical properties show better agreements than those using homogeneous optical properties.

Citation Download Citation

Jun Li, Timothy C. Zhu, and Jarod C. Finlay "Study of light fluence rate distribution in photodynamic therapy using finite-element method", Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 61390M (6 March 2006); https://doi.org/10.1117/12.646251

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