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SPIE Proceedings | Volume 8251 | Plenary Session >
Proceedings Article

New optical, acoustic, and electrical diagnostics for the developing world

[+] Author Affiliations
S. L. Neale, C. Witte, Y. Bourquin, C. Kremer, A. Menachery, Y. Zhang, R. Wilson, J. Reboud, J. M. Cooper

Univ. of Glasgow (United Kingdom)

Proc. SPIE 8251, Microfluidics, BioMEMS, and Medical Microsystems X, 825102 (February 9, 2012); doi:10.1117/12.924357
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Open Access

From Conference Volume 8251

  • Microfluidics, BioMEMS, and Medical Microsystems X
  • Holger Becker; Bonnie L. Gray
  • San Francisco, California, USA | January 21, 2012
Abstract
References

abstract

Infectious diseases cause 10 million deaths each year worldwide, accounting for ~60% of all deaths of children aged 5- 14. Although these deaths arise primarily through pneumonia, TB, malaria and HIV, there are also the so called "neglected diseases" such as sleeping sickness and bilharzia, which have a devastating impact on rural communities, in sub-Sahara Africa. There, the demands for a successful Developing World diagnostic are particularly rigorous, requiring low cost instrumentation with low power consumption (there is often no fixed power infrastructure). In many cases, the levels of infection within individuals are also sufficiently low that instruments must show extraordinary sensitivity, with measurements being made in blood or saliva. In this talk, a description of these demands will be given, together with a review of some of the solutions that have been developed, which include using acoustics, optics and electrotechnologies, and their combinations to manipulate the fluid samples. In one example, we show how to find a single trypanosome, as the causative agent of sleeping sickness.

© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

references

1
Giljohann, D.A., Mirkin, C.A., "Review Article Drivers of biodiagnostic development" Nature 462, 461-464 (2009)10.1038/nature08605
2
Ligler, F.S., "A Perspective on Optical Biosensors and Integrated Sensor Systems" Annu. Rev. Biomed. Eng. . 10:107-44 (2008).
3
Stevens, D.Y., Petri, C.R., Osborn, J.L., Spicar-Mihalic, P., McKenzie, K.G., Yager, P., "Enabling a microfluidic immunoassay for the developing world by integration of on-card dry reagent storage" Lab Chip, 8, 2038-2045 (2008).10.1039/b811158h
4
Martinez, A.W., Phillips, S.T., Whitesides, G.M., "Three-dimensional microfluidic devices fabricated in layered paper and tape" PNAS vol. 105 no. 50 19606-19611 (2008).
5
Nie, Z., Deiss, F., Liu, X., Akbulut, O., Whitesides, G.M., "Integration of paper-based microfluidic devices with commercial electrochemical readers" Lab Chip 10(22): 3163-3169 (2010).
6
Wastling, S.L., Welburn, S.C., "Diagnosis of human sleeping sickness: sense and sensitivity" Trends in Parasitology, 27, 9, 394-402, (2011).10.1016/j.pt.2011.04.005
7
Lord Rayleigh, "On waves propagating along the plane surface of an elastic solid". Proc. London Math. Soc. S1-17 (1): 4-11 (1885).
8
Lamb, H., "On waves in an elastic plate". Proc. Royal Soc. (London) Ser. A 93, 114 (1917).10.1098/rspa.1917.0008
9
Rowen, J.H. (1963) U.S. Patent 3,289,114.
10
Mortley, W.S. (1963) British patent 988,102
11
White, R. M., and Voltmer, F. W., "Direct piezoelectric coupling to surface elastic waves". Appl. Phys. Lett. 7, 314-316 (1965).10.1063/1.1754276
12
Moroney, R.M., White, R.M. and Howe, R.T. "Fluid motion produced by ultrasonic Lamb waves." Proceedings of the IEEE 1990 Ultrasonics Symposium, 355-358 (1990).
13
Kurosawa, M., Watanabe, T. and Higuchi, T. "Surface acoustic wave atomizer with pumping effect", Proceedings of IEEE Micro Electro Mechanical Systems MEMS '95, p25 (1995).
14
Bourquin, Y., Reboud, J., Wilson R. and Cooper, J.M., "Tuneable surface acoustic waves for fluid and particle manipulations on disposable chips", Lab Chip, 10, 1898-1901 (2010).10.1039/c004506c
15
Wilson, R., Reboud, J., Bourquin, Y., Neale, S.L., Zhang, Y., Cooper, J.M., Lab Chip, 11, 323-328 (2011).
16
Bourquin, Y., Wilson, R., Zhang, Y., Reboud, J. and Cooper, J.M., "Phononic Crystals for Shaping Fluids", Adv. Mat., 23, 1458-1462 (2011).10.1002/adma.201004455
17
Bourquin, Y., Reboud, R., Wilson, R., Zhang, Y. and Cooper, J.M., "Integrated immunoassay using tuneable surface acoustic waves and lensfree detection", Lab Chip, 11, 2725-2730 (2011).10.1039/c1lc20320g
18
Bourquin, Y., Reboud, J., Wilson, R., Zhang, Y. and Cooper, J.M., "Low cost diagnostic device using mobile phone technologies", PGBIOMED 2 (2011).
19
Pethig, R., "Dielectrophoresis: Status of the theory, technology, and applications", Biomicrofluidics, 4, pp. 022811-1 - 022811-35 (2010).10.1063/1.3456626
20
Kim, U., Shu, C.W., Dane, K.Y., Daugherty, P.S., Wang, J.Y.J. and Soh, H.T. , "Selection of mammalian cells based on their cell-cycle phase using dielectrophoresis", P.N.A.S., 04, pp. 20708-20712 (2007).10.1073/pnas.0708760104
21
Labeed, F.H., Coley, H. M., Thomas, H. and Hughes, M.P., "Assessment of Multidrug Resistance Reversal Using Dielectrophoresis and Flow Cytometry", Biophysical Journal, 85 pp. 2028-2034 (2003).
22
Vykoukal, J., Vykoukal, D.M., Freyberg, S., Alt, E.U. and Gascoyne, P.R.C., "Enrichment of putative stem cells from adipose tissue using dielectrophoretic field-flow fractionation", Lab Chip, 8, pp. 1386-1393 (2008).10.1039/b717043b
23
Gascoyne, P., Mahidol, C., Ruchirawat, M., Satayavivad, J., Watcharasit, P. and Becker, F. F. "Microsample preparation by dielectrophoresis: isolation of malaria", Lab Chip, 2, pp. 70-75 (2002).10.1039/b110990c
24
Chiou, P. Y., Ohta, A.T. and Wu, M.C., "Massively parallel manipulation of single cells and microparticles using optical images" Nature, 436, 370-372 (2005).10.1038/nature03831
25
Neale, S.L., Mazilu, M., Wilson, J.I.B., Dholakia, K. and Krauss, T.F., "The resolution of optical traps created by Light Induced Dielectrophoresis (LIDEP)." Optics Express, Vol. 15, No. 20, 12619-26 (2007).10.1364/OE.15.012619
26
Neale, S.L., Ohta, A.T., Hsu, H.Y., Valley, J.K., Jamshidi, A. and Wu, M.C., "Trap profiles of projector based optoelectronic tweezers (OET) with HeLa cells", Optics Express 17, 5231-5239 (2009).10.1364/OE.17.005231
27
Neale, S.L., Ohta, A.T., Hsu, H.Y., Valley, J.K., Jamshidi, A. and Wu, M.C., "Motile and non-motile sperm diagnostic manipulation using optoelectronic tweezers", Lab-on-a-chip, 10, 3213-3217 (2010).
28
Valley, J.K., Garcia, M., Swinton, P., Neale, S., Hsu, H.Y., Jamshidi, A. and Wu, M.C., "Optoelectronic tweezers for quantitative assessment of embryo development stage", Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference on, 943 - 946 (2010).
29
Kremer, C., Neale, S., Barrett, M. Cooper, J., "Manipulating blood borne parasites with optoelectronic tweezers (OET)", IOP Photon10 (2010).
30
Khoshmanesh, K., Nahavandi, S., Baratchi, S., Mitchell, A. and Kalantar-Zadeh, K., "Dielectrophoretic platforms for bio-microfluidic systems" Biosens Bioelectron, 26, 1800-1814 (2011).10.1016/j.bios.2010.09.022
31
Laurell, T., Petersson F., and Nilsson, A., "Chip integrated strategies for acoustic separation and manipulation of cells and particles" Chem Soc Rev, 36, 492-506 (2007).10.1039/b601326k
32
Wang, Z. Zhe, J., "Recent advances in particle and droplet manipulation for lab-on-a-chip devices based on surface acoustic waves", Lab Chip, 11, 1280-1285 (2011).10.1039/c0lc00527d
33
Ravula, S.K., Branch, D.W., James, C.D., Townsend, R.J., Hill, M., Kaduchak, G., Ward, M. and Brener, I., "A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing" Sensors and Actuators B: Chemical, 130, 645-652 (2008).10.1016/j.snb.2007.10.024
34
Wiklund, M., Gunther, C., Lemor, R., Jager, M., Fuhr, G. and Hertz, H.M., "Ultrasonic standing wave manipulation technology integrated into a dielectrophoretic chip" Lab Chip, 6, 1537-1544 (2006).10.1039/b612064b
35
Zarowna-Dabrowska, A., Neale, S.L., Massoubre, D., McKendry, J., Rae, B.R., Henderson, R.K., Rose, M.J., Yin, H., Cooper, J.M., Gu, E. and Dawson, M.D., "Miniaturized optoelectronic tweezers controlled by GaN micro-pixel light emitting diode arrays" Opt. Express, 19, 2720-2728 (2011).10.1364/OE.19.002720
36
Valley, J.K., Ohta, A.T., Hsu, H.Y., Neale, S.L., Jamshidi, A. and Wu M.C., "Optoelectronic Tweezers as a tool for parallel single-cell manipulation and stimulation", IEEE Transactions on Biomedical Circuits and Systems, Vol 3, 6, 424-431 (2009).10.1109/TBCAS.2009.2031329
Full text of this article:
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Citation

S. L. Neale ; C. Witte ; Y. Bourquin ; C. Kremer ; A. Menachery ; Y. Zhang ; R. Wilson ; J. Reboud and J. M. Cooper
"New optical, acoustic, and electrical diagnostics for the developing world", Proc. SPIE 8251, Microfluidics, BioMEMS, and Medical Microsystems X, 825102 (February 9, 2012); doi:10.1117/12.924357; http://dx.doi.org/10.1117/12.924357


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Figures

Tables

1
Giljohann, D.A., Mirkin, C.A., "Review Article Drivers of biodiagnostic development" Nature 462, 461-464 (2009)10.1038/nature08605
2
Ligler, F.S., "A Perspective on Optical Biosensors and Integrated Sensor Systems" Annu. Rev. Biomed. Eng. . 10:107-44 (2008).
3
Stevens, D.Y., Petri, C.R., Osborn, J.L., Spicar-Mihalic, P., McKenzie, K.G., Yager, P., "Enabling a microfluidic immunoassay for the developing world by integration of on-card dry reagent storage" Lab Chip, 8, 2038-2045 (2008).10.1039/b811158h
4
Martinez, A.W., Phillips, S.T., Whitesides, G.M., "Three-dimensional microfluidic devices fabricated in layered paper and tape" PNAS vol. 105 no. 50 19606-19611 (2008).
5
Nie, Z., Deiss, F., Liu, X., Akbulut, O., Whitesides, G.M., "Integration of paper-based microfluidic devices with commercial electrochemical readers" Lab Chip 10(22): 3163-3169 (2010).
6
Wastling, S.L., Welburn, S.C., "Diagnosis of human sleeping sickness: sense and sensitivity" Trends in Parasitology, 27, 9, 394-402, (2011).10.1016/j.pt.2011.04.005
7
Lord Rayleigh, "On waves propagating along the plane surface of an elastic solid". Proc. London Math. Soc. S1-17 (1): 4-11 (1885).
8
Lamb, H., "On waves in an elastic plate". Proc. Royal Soc. (London) Ser. A 93, 114 (1917).10.1098/rspa.1917.0008
9
Rowen, J.H. (1963) U.S. Patent 3,289,114.
10
Mortley, W.S. (1963) British patent 988,102
11
White, R. M., and Voltmer, F. W., "Direct piezoelectric coupling to surface elastic waves". Appl. Phys. Lett. 7, 314-316 (1965).10.1063/1.1754276
12
Moroney, R.M., White, R.M. and Howe, R.T. "Fluid motion produced by ultrasonic Lamb waves." Proceedings of the IEEE 1990 Ultrasonics Symposium, 355-358 (1990).
13
Kurosawa, M., Watanabe, T. and Higuchi, T. "Surface acoustic wave atomizer with pumping effect", Proceedings of IEEE Micro Electro Mechanical Systems MEMS '95, p25 (1995).
14
Bourquin, Y., Reboud, J., Wilson R. and Cooper, J.M., "Tuneable surface acoustic waves for fluid and particle manipulations on disposable chips", Lab Chip, 10, 1898-1901 (2010).10.1039/c004506c
15
Wilson, R., Reboud, J., Bourquin, Y., Neale, S.L., Zhang, Y., Cooper, J.M., Lab Chip, 11, 323-328 (2011).
16
Bourquin, Y., Wilson, R., Zhang, Y., Reboud, J. and Cooper, J.M., "Phononic Crystals for Shaping Fluids", Adv. Mat., 23, 1458-1462 (2011).10.1002/adma.201004455
17
Bourquin, Y., Reboud, R., Wilson, R., Zhang, Y. and Cooper, J.M., "Integrated immunoassay using tuneable surface acoustic waves and lensfree detection", Lab Chip, 11, 2725-2730 (2011).10.1039/c1lc20320g
18
Bourquin, Y., Reboud, J., Wilson, R., Zhang, Y. and Cooper, J.M., "Low cost diagnostic device using mobile phone technologies", PGBIOMED 2 (2011).
19
Pethig, R., "Dielectrophoresis: Status of the theory, technology, and applications", Biomicrofluidics, 4, pp. 022811-1 - 022811-35 (2010).10.1063/1.3456626
20
Kim, U., Shu, C.W., Dane, K.Y., Daugherty, P.S., Wang, J.Y.J. and Soh, H.T. , "Selection of mammalian cells based on their cell-cycle phase using dielectrophoresis", P.N.A.S., 04, pp. 20708-20712 (2007).10.1073/pnas.0708760104
21
Labeed, F.H., Coley, H. M., Thomas, H. and Hughes, M.P., "Assessment of Multidrug Resistance Reversal Using Dielectrophoresis and Flow Cytometry", Biophysical Journal, 85 pp. 2028-2034 (2003).
22
Vykoukal, J., Vykoukal, D.M., Freyberg, S., Alt, E.U. and Gascoyne, P.R.C., "Enrichment of putative stem cells from adipose tissue using dielectrophoretic field-flow fractionation", Lab Chip, 8, pp. 1386-1393 (2008).10.1039/b717043b
23
Gascoyne, P., Mahidol, C., Ruchirawat, M., Satayavivad, J., Watcharasit, P. and Becker, F. F. "Microsample preparation by dielectrophoresis: isolation of malaria", Lab Chip, 2, pp. 70-75 (2002).10.1039/b110990c
24
Chiou, P. Y., Ohta, A.T. and Wu, M.C., "Massively parallel manipulation of single cells and microparticles using optical images" Nature, 436, 370-372 (2005).10.1038/nature03831
25
Neale, S.L., Mazilu, M., Wilson, J.I.B., Dholakia, K. and Krauss, T.F., "The resolution of optical traps created by Light Induced Dielectrophoresis (LIDEP)." Optics Express, Vol. 15, No. 20, 12619-26 (2007).10.1364/OE.15.012619
26
Neale, S.L., Ohta, A.T., Hsu, H.Y., Valley, J.K., Jamshidi, A. and Wu, M.C., "Trap profiles of projector based optoelectronic tweezers (OET) with HeLa cells", Optics Express 17, 5231-5239 (2009).10.1364/OE.17.005231
27
Neale, S.L., Ohta, A.T., Hsu, H.Y., Valley, J.K., Jamshidi, A. and Wu, M.C., "Motile and non-motile sperm diagnostic manipulation using optoelectronic tweezers", Lab-on-a-chip, 10, 3213-3217 (2010).
28
Valley, J.K., Garcia, M., Swinton, P., Neale, S., Hsu, H.Y., Jamshidi, A. and Wu, M.C., "Optoelectronic tweezers for quantitative assessment of embryo development stage", Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference on, 943 - 946 (2010).
29
Kremer, C., Neale, S., Barrett, M. Cooper, J., "Manipulating blood borne parasites with optoelectronic tweezers (OET)", IOP Photon10 (2010).
30
Khoshmanesh, K., Nahavandi, S., Baratchi, S., Mitchell, A. and Kalantar-Zadeh, K., "Dielectrophoretic platforms for bio-microfluidic systems" Biosens Bioelectron, 26, 1800-1814 (2011).10.1016/j.bios.2010.09.022
31
Laurell, T., Petersson F., and Nilsson, A., "Chip integrated strategies for acoustic separation and manipulation of cells and particles" Chem Soc Rev, 36, 492-506 (2007).10.1039/b601326k
32
Wang, Z. Zhe, J., "Recent advances in particle and droplet manipulation for lab-on-a-chip devices based on surface acoustic waves", Lab Chip, 11, 1280-1285 (2011).10.1039/c0lc00527d
33
Ravula, S.K., Branch, D.W., James, C.D., Townsend, R.J., Hill, M., Kaduchak, G., Ward, M. and Brener, I., "A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing" Sensors and Actuators B: Chemical, 130, 645-652 (2008).10.1016/j.snb.2007.10.024
34
Wiklund, M., Gunther, C., Lemor, R., Jager, M., Fuhr, G. and Hertz, H.M., "Ultrasonic standing wave manipulation technology integrated into a dielectrophoretic chip" Lab Chip, 6, 1537-1544 (2006).10.1039/b612064b
35
Zarowna-Dabrowska, A., Neale, S.L., Massoubre, D., McKendry, J., Rae, B.R., Henderson, R.K., Rose, M.J., Yin, H., Cooper, J.M., Gu, E. and Dawson, M.D., "Miniaturized optoelectronic tweezers controlled by GaN micro-pixel light emitting diode arrays" Opt. Express, 19, 2720-2728 (2011).10.1364/OE.19.002720
36
Valley, J.K., Ohta, A.T., Hsu, H.Y., Neale, S.L., Jamshidi, A. and Wu M.C., "Optoelectronic Tweezers as a tool for parallel single-cell manipulation and stimulation", IEEE Transactions on Biomedical Circuits and Systems, Vol 3, 6, 424-431 (2009).10.1109/TBCAS.2009.2031329

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