Role of speckles in laser Doppler perfusion imaging: an investigation on particle suspensions

Vinayakrishnan Rajan; Babu Varghese; Ton G. van Leeuwen; Wiendelt Steenbergen

doi:10.1117/12.661601

14 April 2006 Role of speckles in laser Doppler perfusion imaging: an investigation on particle suspensions

Vinayakrishnan Rajan, Babu Varghese, Ton G. van Leeuwen, Wiendelt Steenbergen

Proceedings Volume 6191, Biophotonics and New Therapy Frontiers; 619113 (2006) https://doi.org/10.1117/12.661601
Event: SPIE Photonics Europe, 2006, Strasbourg, France

Abstract

We show that speckles play an important role in laser Doppler perfusion imaging. The influence of speckles on the signal amplitude and the Doppler spectrum is demonstrated experimentally on particle suspensions with different scattering levels and varying beam width. Polystyrene microsphere suspensions with known optical properties are used to make scattering samples. A theoretical model is explained to calculate the speckle size from the back scattered intensity distributions. The coherence area is calculated with Monte Carlo simulations on different scattering samples and experiments are performed to validate our theoretical model. The experimental results are in good agreement with our theoretical predictions.

Citation Download Citation

Vinayakrishnan Rajan, Babu Varghese, Ton G. van Leeuwen, and Wiendelt Steenbergen "Role of speckles in laser Doppler perfusion imaging: an investigation on particle suspensions", Proc. SPIE 6191, Biophotonics and New Therapy Frontiers, 619113 (14 April 2006); https://doi.org/10.1117/12.661601

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