A lenslet-based device for measuring oxygen saturation in the retina

Jessica C. Ramella-Roman; H. Kandimalla; R. Dinga; A. Nabili; Scott A. Mathews; Q. D. Nguyen

doi:10.1117/12.714123

5 March 2007 A lenslet-based device for measuring oxygen saturation in the retina

Jessica C. Ramella-Roman, H. Kandimalla, R. Dinga, A. Nabili, Scott A. Mathews, Q. D. Nguyen

Proceedings Volume 6426, Ophthalmic Technologies XVII; 64261J (2007) https://doi.org/10.1117/12.714123
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Diabetic retinopathy (DR) is a complication of diabetes affecting up to 80% of all diabetic patients. DR can lead to blindness and reduced quality of life. Some authors have hypothesized that changes in the flow dynamics associated with DR as well as changes in retinal oxygenation can lead to macular edema. Measurements of oxygen saturation in the retina could help understand the real mechanisms behind this condition. We present a novel spectroscopic imaging device to measure oxygen saturation in the retina. Our system uses a lenslet array to spatially and spectrocopically divide a fundus image. A three wavelengths algorithm is used to calculate oxygen saturation in small vessels. Only wavelengths in the 500 - 580 nm range are considered in order to minimize the wavelength dependence of the scattering from erythrocytes. Preliminary testing on healthy subjects showed values of oxygen saturation comparable to the one reported in the literature.

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Jessica C. Ramella-Roman, H. Kandimalla, R. Dinga, A. Nabili, Scott A. Mathews, and Q. D. Nguyen "A lenslet-based device for measuring oxygen saturation in the retina", Proc. SPIE 6426, Ophthalmic Technologies XVII, 64261J (5 March 2007); https://doi.org/10.1117/12.714123

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KEYWORDS

Oxygen

Retina

Cameras

Imaging systems

Blood

Scattering

Spectroscopy

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