Three-dimensional photoacoustic imaging of vascular anatomy in small animals using an optical detection system

Edward Z. Zhang; Jan Laufer; Paul Beard

doi:10.1117/12.700128

13 February 2007 Three-dimensional photoacoustic imaging of vascular anatomy in small animals using an optical detection system

Edward Z. Zhang, Jan Laufer, Paul Beard

Author Affiliations +

Proceedings Volume 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 64370S (2007) https://doi.org/10.1117/12.700128
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

A 3D photoacoustic imaging instrument for characterising small animal models of human disease processes has been developed. The system comprises an OPO excitation source and a backward-mode planar ultrasound imaging head based upon a Fabry Perot polymer film sensing interferometer (FPI). The mirrors of the latter are transparent between 590 - 1200nm but highly reflective between 1500-1600nm. This enables nanosecond excitation laser pulses in the former wavelength range, where biological tissues are relatively transparent, to be transmitted through the sensor head into the tissue. The resulting photoacoustic signals arrive at the sensor where they modulate the optical thickness of the FPI and therefore its reflectivity. By scanning a CW focused interrogating laser beam at 1550nm across the surface of the sensor, the spatial-temporal distribution of the photoacoustic signals can therefore be mapped in 2D enabling a 3D photoacoustic image to be reconstructed. To demonstrate the application of the system to imaging small animals such as mice, 3D images of the vascular anatomy of the mouse brain and the microvasculature in the skin around the abdomen were obtained non invasively. It is considered that this system provides a practical alternative to photoacoustic scanners based upon piezoelectric detectors for high resolution non invasive small animal imaging.

Citation Download Citation

Edward Z. Zhang, Jan Laufer, and Paul Beard "Three-dimensional photoacoustic imaging of vascular anatomy in small animals using an optical detection system", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64370S (13 February 2007); https://doi.org/10.1117/12.700128

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