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Proceedings Article

Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system

[+] Author Affiliations
Sergey Ermilov, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Alexander Oraevsky

Fairway Medical Technologies

Alan Stein, Scott Thompson

Seno Medical Instruments

Pamela Otto, Barbara McCorvey

The Univ. of Texas Health Science Ctr. at San Antonio

Tuenchit Khamapirad, Morton Leonard

The Univ. of Texas Medical Branch at Galveston

Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643703 (February 15, 2007); doi:10.1117/12.714039
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From Conference Volume 6437

  • Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
  • Alexander A. Oraevsky; Lihong V. Wang
  • San Jose, CA | January 20, 2007

abstract

We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small (less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images obtained at 1064 nm and 757 nm.

© (2007) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Sergey Ermilov ; Alan Stein ; Andre Conjusteau ; Reda Gharieb ; Ron Lacewell, et al.
"Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643703 (February 15, 2007); doi:10.1117/12.714039; http://dx.doi.org/10.1117/12.714039


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