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Proceedings Article

Intelligent spectral signature bio-imaging in vivo for surgical applications

[+] Author Affiliations
Jihoon Jeong, Jae Y. Hwang, Daniel L. Farkas

Univ. of Southern California, Los Angeles and Cedars-Sinai Medical Ctr.

Philip K. Frykman, Mark Gaon, Alice P. Chung, Erik H. Lindsley

Cedars-Sinai Medical Ctr.

Proc. SPIE 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, 64411N (February 19, 2007); doi:10.1117/12.712412
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From Conference Volume 6441

  • Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V
  • Daniel L. Farkas; Robert C. Leif; Dan V. Nicolau
  • San Jose, CA | January 20, 2007

abstract

Multi-spectral imaging provides digital images of a scene or object at a large, usually sequential number of wavelengths, generating precise optical spectra at every pixel. We use the term "spectral signature" for a quantitative plot of optical property variations as a function of wavelengths. We present here intelligent spectral signature bio-imaging methods we developed, including automatic signature selection based on machine learning algorithms and database search-based automatic color allocations, and selected visualization schemes matching these approaches. Using this intelligent spectral signature bio-imaging method, we could discriminate normal and aganglionic colon tissue of the Hirschsprung's disease mouse model with over 95% sensitivity and specificity in various similarity measure methods and various anatomic organs such as parathyroid gland, thyroid gland and pre-tracheal fat in dissected neck of the rat in vivo .

© (2007) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Jihoon Jeong ; Philip K. Frykman ; Mark Gaon ; Alice P. Chung ; Erik H. Lindsley, et al.
"Intelligent spectral signature bio-imaging in vivo for surgical applications", Proc. SPIE 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, 64411N (February 19, 2007); doi:10.1117/12.712412; http://dx.doi.org/10.1117/12.712412


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