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The possibility of spatial resolved reflectometry (SRR) application at wavelength of 820 nm for the detection of
changes in optical properties of multilayer scattering medium was considered. The considered changes
correspond to changes induced by glucose level variations in model biotissue. The model signals from a 3-layer
biotissue phantom mimicking two skin layers and a blood layer between them were obtained by implementing
Monte Carlo technique. It was supposed that changes in the glucose level induce changes in the blood layer and
the deeper skin layer. In order to analyze the trajectories of the photons contributing to the signal, the scattering
maps were obtained. Relative changes of the signal induced by the glucose level variations was analyzed for
different source-detector separations. It was shown that the maximal relative change of the signal of about 7%
corresponding to the glucose concentration change from 0 to 500 mg/dl takes place for source-detector
separations in the range from 0.3 to 0.5 mm depending on the model parameters.
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Mikhail Yu. Kirillin, Alexander V. Bykov, Alexander V. Priezzhev, Risto Myllyla, "Glucose sensing in biotissue phantom by spatial resolved reflectometry: Monte Carlo simulations," Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 65343A (1 May 2007); https://doi.org/10.1117/12.741513