Monitoring changes in the scattering properties of mouse skin with optical coherence tomography during an in vivo glucose tolerance test

M. Kinnunen; S. Tausta; R. Myllylä; S. Vainio

doi:10.1117/12.740621

26 April 2007 Monitoring changes in the scattering properties of mouse skin with optical coherence tomography during an in vivo glucose tolerance test

M. Kinnunen, S. Tausta, R. Myllylä, S. Vainio

Author Affiliations +

Proceedings Volume 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII; 65350B (2007) https://doi.org/10.1117/12.740621
Event: Saratov Fall Meeting 2006, 2006, Saratov, Russian Federation

Abstract

A non-invasive glucose monitoring technique would make evaluation of blood glucose values easier and more convenient. This would help diabetic patients to control their blood glucose values more regularly. A few years ago optical coherence tomography (OCT) was proposed as a non-invasive sensor for monitoring changes in blood glucose concentration. The method is based on monitoring glucose-induced changes in the scattering properties of the target. This article describes how OCT was used to monitor changes in the scattering properties of mouse skin during an in vivo glucose tolerance test. The results show that OCT has the potential to register glucose-induced changes in the optical properties of the sample. However, a commercial OCT device with a probe designed for imaging is not very suitable for non-invasive monitoring of glucose-induced changes in scattering. The problems confronted in this study, possibly originating from the small size of the animals, are discussed in the article.

Citation Download Citation

M. Kinnunen, S. Tausta, R. Myllylä, and S. Vainio "Monitoring changes in the scattering properties of mouse skin with optical coherence tomography during an in vivo glucose tolerance test", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65350B (26 April 2007); https://doi.org/10.1117/12.740621

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available