Investigation of skin water loss and glycerol delivery through stratum corneum

Elina A. Genina; Anastasiya A. Korobko; Alexey N. Bashkatov; Valery V. Tuchin; Ilya V. Yaroslavsky; Gregory B. Altshuler

doi:10.1117/12.740990

26 April 2007 Investigation of skin water loss and glycerol delivery through stratum corneum

Elina A. Genina, Anastasiya A. Korobko, Alexey N. Bashkatov, Valery V. Tuchin, Ilya V. Yaroslavsky, Gregory B. Altshuler

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Proceedings Volume 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII; 65351G (2007) https://doi.org/10.1117/12.740990
Event: Saratov Fall Meeting 2006, 2006, Saratov, Russian Federation

Abstract

Investigation of skin water loss and clearing agent delivery through stratum corneum is presented. Effectiveness of the method "lattice of islets of damage" for enhancement of stratum corneum permeability for water and 71% glycerol solution providing the skin clearing was investigated. Dehydration induced by both stimuli evaporation and osmotic agent action was studied by weight measurements. Measurements of refractive index dynamics of glycerol and water during its interaction with skin samples were carried out. The results have shown that proposed method allows effective transepidermal water loss and delivery of optical clearing agents.

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Elina A. Genina, Anastasiya A. Korobko, Alexey N. Bashkatov, Valery V. Tuchin, Ilya V. Yaroslavsky, and Gregory B. Altshuler "Investigation of skin water loss and glycerol delivery through stratum corneum", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351G (26 April 2007); https://doi.org/10.1117/12.740990

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