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Proceedings Article

Dual-modal (OIS/LSCI) imager of cerebral cortex in freely moving animals

[+] Author Affiliations
Hongyang Lu, Peng Miao, Qi Liu, Yao Li, Shanbao Tong

Shanghai Jiaotong Univ. (China)

Proc. SPIE 8329, Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011), 83290P (March 13, 2012); doi:10.1117/12.919133
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From Conference Volume 8329

  • Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011)
  • Wuhan, China | November 02, 2011

abstract

Optical intrinsic signals (OIS) and laser speckle contrast imaging (LSCI) have been used for years in the study of the cerebral blood flow (CBF) and hemodynamic responses to the neural activity under functional stimulation. So far, most in vivo rodent experiments are based on the anesthesia model when the animals are in unconscious and restrained conditions. The influences of anesthesia on the neural activity have been documented in literature. In this study, we designed a miniature head-mounted dual-modal imager in freely moving animals that could monitor in real time the coupling of local oxygen consumption and blood perfusion of CBF by integrating different imaging modalities of OIS and LSCI. The system facilitates the study the cortical hemodynamics and neural-hemodynamic coupling in real time in freely moving animals.

© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Hongyang Lu ; Peng Miao ; Qi Liu ; Yao Li and Shanbao Tong
"Dual-modal (OIS/LSCI) imager of cerebral cortex in freely moving animals", Proc. SPIE 8329, Tenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2011), 83290P (March 13, 2012); doi:10.1117/12.919133; http://dx.doi.org/10.1117/12.919133


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