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Proceedings Article

Comparison of OPO and Mark-III FEL for tissue ablation at 6.45 μm

[+] Author Affiliations
Glenn S. Edwards, M. Shane Hutson, Susanne Hauger

Duke Univ. (USA)

John A. Kozub, Jin-Hui Shen, Charles Shieh, Katie Topadze, Karen Joos

Vanderbilt Univ. (USA)

Proc. SPIE 4633, Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers, 194 (April 5, 2002); doi:10.1117/12.461379
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From Conference Volume 4633

  • Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers
  • Glenn S. Edwards; Joseph Neev; Andreas Ostendorf; John C. Sutherland
  • San Jose, CA | January 18, 2002

abstract

We have investigated the experimental consequences of two picosecond infrared lasers, both tuned to 6.45micrometers and focused on ocular tissue. The exposure conditions were comparable, other than pulse repetition rate, where an optical parametric oscillator/amplifier laser (OPA) system operates at a kilohertz and the Mark-III FEL at 3 gigahertz. In both cases, the peak intensity was near 2x1014 W/m2 and the total delivered energy was approximately 125 mJ. The Mark-III consistently ablates tissue, while the OPA fails to ablate or to damage corneal tissue. In particular, there is no experimental evidence for protein denaturation due to OPA irradiation. WE account for these observations in terms of a theoretical model based on thermal diffusion and threshold conditions for superheating and chemical kinetics. We comment on the relevance of tissue geometry.

© (2002) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Glenn S. Edwards ; M. Shane Hutson ; Susanne Hauger ; John A. Kozub ; Jin-Hui Shen, et al.
"Comparison of OPO and Mark-III FEL for tissue ablation at 6.45 μm", Proc. SPIE 4633, Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers, 194 (April 5, 2002); doi:10.1117/12.461379; http://dx.doi.org/10.1117/12.461379


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