Comparison of OPO and Mark-III FEL for tissue ablation at 6.45 um

Glenn S. Edwards; M. Shane Hutson; Susanne Hauger; John A. Kozub; Jin-Hui Shen; Charles Shieh; Katie Topadze; Karen Joos

doi:10.1117/12.461379

1 April 2002 Comparison of OPO and Mark-III FEL for tissue ablation at 6.45 μm

Glenn S. Edwards, M. Shane Hutson, Susanne Hauger, John A. Kozub, Jin-Hui Shen, Charles Shieh, Katie Topadze, Karen Joos

Author Affiliations +

Proceedings Volume 4633, Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers; (2002) https://doi.org/10.1117/12.461379
Event: High-Power Lasers and Applications, 2002, San Jose, California, United States

Abstract

We have investigated the experimental consequences of two picosecond infrared lasers, both tuned to 6.45micrometers and focused on ocular tissue. The exposure conditions were comparable, other than pulse repetition rate, where an optical parametric oscillator/amplifier laser (OPA) system operates at a kilohertz and the Mark-III FEL at 3 gigahertz. In both cases, the peak intensity was near 2x10¹⁴ W/m² and the total delivered energy was approximately 125 mJ. The Mark-III consistently ablates tissue, while the OPA fails to ablate or to damage corneal tissue. In particular, there is no experimental evidence for protein denaturation due to OPA irradiation. WE account for these observations in terms of a theoretical model based on thermal diffusion and threshold conditions for superheating and chemical kinetics. We comment on the relevance of tissue geometry.

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Glenn S. Edwards, M. Shane Hutson, Susanne Hauger, John A. Kozub, Jin-Hui Shen, Charles Shieh, Katie Topadze, and Karen Joos "Comparison of OPO and Mark-III FEL for tissue ablation at 6.45 μm", Proc. SPIE 4633, Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers, (1 April 2002); https://doi.org/10.1117/12.461379

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