Eight-channel time-resolved tissue oximeter for functional muscle studies

Rinaldo Cubeddu; Giovanni Biscotti; Antonio Pifferi; Paola Taroni; Alessandro Torricelli; Marco Ferrari; Valentina Quaresima

doi:10.1117/12.478132

29 July 2003 Eight-channel time-resolved tissue oximeter for functional muscle studies

Rinaldo Cubeddu, Giovanni Biscotti, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, Marco Ferrari, Valentina Quaresima

Author Affiliations +

Proceedings Volume 4955, Optical Tomography and Spectroscopy of Tissue V; (2003) https://doi.org/10.1117/12.478132
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

A portable instrument for tissue oximetry based on time-resolved reflectance spectroscopy was developed. The output pulses of 2 laser diodes (683 and 785 nm, 80 MHz pulse repetition rate, 1 mW average power, 100 ps FWHM) are delayed and coupled into a multimode graded-index fiber (50/125 μm and injected into the tissue. The reflectance photons are collected by 8 independent 1 mm fibers and detected by a 16-anode photomultiplier. A time-correlated single photon counting PC board is used for the parallel acquisition of the curves. Simultaneous estimate of the transport scattering and absorption coefficients is achieved by best fitting of time-resolved reflectance curves with a standard model of Diffusion Theory. The performances of the system were tested on phantoms in terms of stability, reproducibility among channels, and accuracy in the determination of the optical properties. Preliminary in vivo measurements were performed on healthy volunteers to monitor spatial changes in calf (medical and lateral gastrocnemius) oxygen hemoglobin saturation and blood volume during dynamic plantar flexion exercise.

Citation Download Citation

Rinaldo Cubeddu, Giovanni Biscotti, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, Marco Ferrari, and Valentina Quaresima "Eight-channel time-resolved tissue oximeter for functional muscle studies", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); https://doi.org/10.1117/12.478132

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