A multidisciplinary analysis is demonstrated for the NEXUS space telescope precursor mission. This mission was originally designed as an in-space technology testbed for the Next Generation Space Telescope (NGST). One of the main challenges is to achieve a very tight pointing accuracy with a sub-pixel line-of-sight (LOS) jitter budget and a root-mean-square (RMS) wavefront error smaller than λ/50 despite the presence of electronic and mechanical disturbances sources. The analysis starts with the assessment of the performance for an initial design, which turns out not to meet the requirements. Twentyfive design parameters from structures, optics, dynamics and controls are then computed in a sensitivity and isoperformance analysis, in search of better designs. Isoperformance allows finding an acceptable design that is well "balanced" and does not place undue burden on a single subsystem. An error budget analysis shows the contributions of individual disturbance sources. This paper might be helpful in analyzing similar, innovative space telescope systems in the future.© (2002) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.