Hemodynamic responses to functional activation accessed by optical imaging

Songlin Ni; Pengcheng Li; Yuanyuan Yang; Xiaohua Lv; Qingming Luo

doi:10.1117/12.667100

2 February 2006 Hemodynamic responses to functional activation accessed by optical imaging

Songlin Ni, Pengcheng Li, Yuanyuan Yang, Xiaohua Lv, Qingming Luo

Proceedings Volume 6026, ICO20: Biomedical Optics; 602607 (2006) https://doi.org/10.1117/12.667100
Event: ICO20:Optical Devices and Instruments, 2005, Changchun, China

Abstract

A multi-wavelength light-emitting diode (LED) and laser diode (LD) based optical imaging system was developed to visualize the changes in cerebral blood flow, oxygenation following functional activation simultaneously in rodent cortex. The 2-D blood flow image was accessed by laser speckle contrast imaging, and the spectroscopic imaging of intrinsic signal was used for the calculation of oxyhemoglobin (HbO), deoxyhemoglobin (Hb) and total hemoglobin (HbT) concentration. The combination of spectroscopic imaging and laser speckle contrast imaging provides the capability to simultaneously investigate the spatial and temporal blood flow and hemoglobin concentration changes with high resolution, which may lead to a better understanding of the coupling between neuronal activation and vascular responses. The optical imaging system been built is compact and convenient to investigators. And it is reliable to acquire raw data. In present study, the hemodynamic responses to cortical spreading depression (CSD) in parietal cortex of ∝-chloralose/urethan anesthetized rats were demonstrated.

Citation Download Citation

Songlin Ni, Pengcheng Li, Yuanyuan Yang, Xiaohua Lv, and Qingming Luo "Hemodynamic responses to functional activation accessed by optical imaging", Proc. SPIE 6026, ICO20: Biomedical Optics, 602607 (2 February 2006); https://doi.org/10.1117/12.667100

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