Low-frequency phased-array 2D fluorescence localization in breast cancer detection

Qian Liu; Yu Chen; Britton Chance; Qingming Luo

doi:10.1117/12.546147

8 December 2003 Low-frequency phased-array 2D fluorescence localization in breast cancer detection

Qian Liu, Yu Chen, Britton Chance, Qingming Luo

Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546147
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China

Abstract

A method for rapid, non-invasive 2D fluorescence localization of breast cancer using low frequency phased array near-infrared technique is presented in this article. In our study, we have developed a dual-channel fluorescence detection system to locate breast cancer. This system consists two pair of in-phase and out-of-phase light emitting diodes (LEDs) as the light sources and Photomultiplier Tube (PMT) as the detector. Two null planes generated by cancellation of diffusion photon density waves (DPDW) will indicate the 2D position of breast cancer with exogenous contrast agents. The fluorescent contrast agent used in this study is Indocyanine Green (ICG) and the minimum amount of ICG detected by our system is 0.5 μM. With the 2 cm separation of sources and detector, the maximum depth our system can detect is 10 mm. The whole system is in compact size and portable. Phantom experiments show that the system can provide real time detection and localization of small hidden absorbing-fluorescent objects inside the highly scattering medium with high accuracy of ±3 mm. The potential application is that it is low-cost and can be used for breast cancer localization as operation aid and self-examination.

Citation Download Citation

Qian Liu, Yu Chen, Britton Chance, and Qingming Luo "Low-frequency phased-array 2D fluorescence localization in breast cancer detection", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); https://doi.org/10.1117/12.546147

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Luminescence

Breast cancer

Signal detection

Absorption

Phased arrays

Sensors

Breast

Show All Keywords

Keywords/Phrases

Search In:

Publication Years