Doppler optical coherence tomography for monitoring the vascular effects of photodynamic therapy

Maggie L. Gordon; Victor X. D. Yang; Emily Seng Yue; Stewart S. W. Lo; Brian C. Wilson; I. Alex Vitkin

doi:10.1117/12.527794

1 July 2004 Doppler optical coherence tomography for monitoring the vascular effects of photodynamic therapy

Maggie L. Gordon, Victor X. D. Yang, Emily Seng Yue, Stewart S. W. Lo, Brian C. Wilson, I. Alex Vitkin

Proceedings Volume 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII; (2004) https://doi.org/10.1117/12.527794
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Doppler optical coherence tomography (DOCT) is a powerful tool for providing not only subsurface microstructural, but also functional information. Our group's system is able to image blood vessels as small as ~ 30 μm in diameter, with blood flows as slow as ~ 20 μm/s. Photodynamic therapy (PDT), once a "novel" cancer treatment, is now a major research field in biophotonics and is gaining clinical popularity. The highly sensitive DOCT system was used to image microcirculation in normal rat colon and a rat prostate cancer model before, during, and after PDT. The results demonstrate that DOCT can monitor the vascular changes during PDT and that DOCT can highlight the differences in tissue response with different treatment protocols. Furthermore, DOCT demonstrated differences in response between normal and cancerous tissues.

Citation Download Citation

Maggie L. Gordon, Victor X. D. Yang, Emily Seng Yue, Stewart S. W. Lo, Brian C. Wilson, and I. Alex Vitkin "Doppler optical coherence tomography for monitoring the vascular effects of photodynamic therapy", Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); https://doi.org/10.1117/12.527794

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available