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Proceedings Article

Full-field OCT: applications in ophthalmology

[+] Author Affiliations
Kate Grieve, Arnaud Dubois

Ecole Superieure de Physique et de Chimie Industrielles (France)

Michel Paques

Fondation Ophtalmologique Rothschild (France) and Unite INSERM 592 (France)

Jean-Francois Le Gargasson

Unite INSERM 592 (France)

Albert C. Boccara

Ecole Superieure de Physique et de Chimie Industrielles, CNRS (France)

Proc. SPIE 5688, Ophthalmic Technologies XV, 77 (May 02, 2005); doi:10.1117/12.588649
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From Conference Volume 5688

  • Ophthalmic Technologies XV
  • Fabrice Manns; Per G. Soederberg; Arthur Ho; Bruce E. Stuck; Michael Belkin
  • San Jose, CA | January 22, 2005

abstract

We present images of ocular tissues obtained using ultrahigh resolution full-field OCT. The experimental setup is based on the Linnik interferometer, illuminated by a tungsten halogen lamp. En face tomographic images are obtained in real-time without scanning by computing the difference of two phase-opposed interferometric images recorded by a high-resolution CCD camera. A spatial resolution of 0.7 μm × 0.9 μm (axial × transverse) is achieved thanks to the short source coherence length and the use of high numerical aperture microscope objectives. A detection sensitivity of 90 dB is obtained by means of image averaging and pixel binning. Whole unfixed eyes and unstained tissue samples (cornea, lens, retina, choroid and sclera) of ex vivo rat, mouse, rabbit and porcine ocular tissues were examined. The unprecedented resolution of our instrument allows cellular-level resolution in the cornea and retina, and visualization of individual fibers in the lens. Transcorneal lens imaging was possible in all animals, and in albino animals, transscleral retinal imaging was achieved. We also introduce our rapid acquisition full-field optical coherence tomography system designed to accommodate in vivo ophthalmologic imaging. The variations on the original system technology include the introduction of a xenon arc lamp as source, and rapid image acquisition performed by a high-speed CMOS camera, reducing acquisition time to 5 ms per frame.

© (2005) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Kate Grieve ; Arnaud Dubois ; Michel Paques ; Jean-Francois Le Gargasson and Albert C. Boccara
"Full-field OCT: applications in ophthalmology", Proc. SPIE 5688, Ophthalmic Technologies XV, 77 (May 02, 2005); doi:10.1117/12.588649; http://dx.doi.org/10.1117/12.588649


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