Ultra-sensitive monitoring of analyte concentrations using phase sensitive spectral domain OCT

V. G. R. Manne; R. K. Manapuram; N. Sudheendran; Kirill V. Larin

doi:10.1117/12.803969

9 June 2008 Ultra-sensitive monitoring of analyte concentrations using phase sensitive spectral domain OCT

V. G. R. Manne, R. K. Manapuram, N. Sudheendran, Kirill V. Larin

Proceedings Volume 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX; 67910A (2008) https://doi.org/10.1117/12.803969
Event: Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 2006, Saratov, Russian Federation

Abstract

The refractive index is a basic optical property of a medium which is of great importance in physics, chemistry and most of biomedical applications. In our current study we monitor the change in refractive index for aqueous solutions of glucose, CaCl₂, MgCl₂, NaCl, KCl and urea using a phase sensitive spectral domain optical coherence tomography (ph-SOCT) system. For instance, glucose induced changes in the phase are found to be 0.079 rad/mM in 200μm thick cuvette for clear media and that is in good agreement with literature and our previous obtained data using phase sensitive low coherence optical reflectometry(PS-OLCR). The importance of this study is to demonstrate the capability of ph-SOCT to monitor ultra small changes in refractive index in clear media and the accuracy for glucose sensing is estimated to be ±2.6×10^-6.

Citation Download Citation

V. G. R. Manne, R. K. Manapuram, N. Sudheendran, and Kirill V. Larin "Ultra-sensitive monitoring of analyte concentrations using phase sensitive spectral domain OCT", Proc. SPIE 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 67910A (9 June 2008); https://doi.org/10.1117/12.803969

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