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Proceedings Article

Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography

[+] Author Affiliations
Wen-Chuan Kuo, Ming-Wei Hsiung, Po-Nien Yang

National Taiwan Normal Univ. (Taiwan)

Jeou-Jong Shyu

National Taiwan Univ. (Taiwan)

Nai-Kuan Chou

National Taiwan Univ. Hospital (Taiwan)

Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684223 (February 08, 2008); doi:10.1117/12.762170
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From Conference Volume 6842

  • Photonic Therapeutics and Diagnostics IV
  • Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen
  • San Jose, CA | January 19, 2008

abstract

In this research, we have used an algorithm to extract four different optical parameters, including the scattering coefficient (μs ), effective anisotropy factor (goff ), birefringence coefficient (Δn), and fast-axis angle (β) from polarization-sensitive optical coherence tomography (PS-OCT) images. The proposed method was evaluated from a set of phantoms and it yielded valid results. We demonstrate that the optical characteristic of normal and different kinds of atherosclerotic lesions in human vessel can be quantitatively described. Whether change in these quantified optical properties could be used to discriminate between different types of human atherosclerotic plaques was examined.

© (2008) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Wen-Chuan Kuo ; Ming-Wei Hsiung ; Jeou-Jong Shyu ; Nai-Kuan Chou and Po-Nien Yang
"Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography", Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684223 (February 08, 2008); doi:10.1117/12.762170; http://dx.doi.org/10.1117/12.762170


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