Measurement of microfluidic flow velocity profile with two Doppler optical coherence tomography systems

Janne Lauri; Meng Wang; Matti Kinnunen; Risto Myllylä

doi:10.1117/12.768500

22 February 2008 Measurement of microfluidic flow velocity profile with two Doppler optical coherence tomography systems

Janne Lauri, Meng Wang, Matti Kinnunen, Risto Myllylä

Author Affiliations +

Proceedings Volume 6863, Optical Diagnostics and Sensing VIII; 68630F (2008) https://doi.org/10.1117/12.768500
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Doppler Optical Coherence Tomography (DOCT) is a useful technique for flow measurements. Its potential applications include industrial suspension viscosity measurements and blood flow measurements. In this work, a flow velocity profile of 1% Intralipid was measured in a capillary with an inner diameter of 0.8 mm and in a microfluidic channel with a cross-section of 1000 μmx100 μm. Two different DOCT measurement systems were utilized in the experiments: a commercial conventional OCT system and a laboratory-built DOCT system, intended particularly for flow velocity measurements. In the laboratory-built DOCT system, depth scanning was achieved by moving the whole measurement system with the reference mirror fixed. This modification from a conventional OCT system improves lateral resolution during the scanning process. A syringe pump was used to induce flow in the capillary. Flow velocity was measured with flow rates from 1 ml/min to 3.33 ml/min using both measurement systems. For a flow rate of 3.33 ml/min, both systems gave reasonable results. For flow rates lower than 3.33 ml/min, however, the laboratory-built DOCT system gave much better results. Its mean measurement error was as low as 0.8%, while that of the commercial OCT was 6.8%. Measured with the laboratory-built DOCT system, capillary force-induced flow velocity in the microfluidic channel was around 2 mm/s. The commercial OCT system, on the other hand, proved unsuitable for flow measurements in the microfluidic channel due to its high scanning speed.

Citation Download Citation

Janne Lauri, Meng Wang, Matti Kinnunen, and Risto Myllylä "Measurement of microfluidic flow velocity profile with two Doppler optical coherence tomography systems", Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630F (22 February 2008); https://doi.org/10.1117/12.768500

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