Protein profile study of clinical samples using laser induced fluorescence as the detection method: case of malignant and normal cervical tissues

Gopal Karemore; Sujatha N. Raja; Lavanya Rai; V. B. Kartha; Santhosh Chidangil

doi:10.1117/12.809972

23 February 2009 Protein profile study of clinical samples using laser induced fluorescence as the detection method: case of malignant and normal cervical tissues

Gopal Karemore, Sujatha N. Raja, Lavanya Rai, V. B. Kartha, Santhosh Chidangil

Author Affiliations +

Proceedings Volume 7169, Advanced Biomedical and Clinical Diagnostic Systems VII; 71691I (2009) https://doi.org/10.1117/12.809972
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Protein profiles of tissue homogenates were recorded using HPLC separation and LIF detection method. The samples were collected from volunteers with clinically normal or cervical cancer conditions. It is shown that the protein profile can be classified as belonging to malignant or normal state by using hard and Fuzzy clustering methods. The study was performed to test the utility of the HPLC-LIF protein profiling method for classification of tissue samples as well as to establish a complementary method for histopathology for clinical diagnosis of the tissue as normal or malignant.

Citation Download Citation

Gopal Karemore, Sujatha N. Raja, Lavanya Rai, V. B. Kartha, and Santhosh Chidangil "Protein profile study of clinical samples using laser induced fluorescence as the detection method: case of malignant and normal cervical tissues", Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71691I (23 February 2009); https://doi.org/10.1117/12.809972

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