An approach to parameter estimation for breast tumor by finite element method

A-qing Xu; Hong-qin Yang; Zhen Ye; Yi-ming Su; Shu-sen Xie

doi:10.1117/12.809082

20 February 2009 An approach to parameter estimation for breast tumor by finite element method

A-qing Xu, Hong-qin Yang, Zhen Ye, Yi-ming Su, Shu-sen Xie

Proceedings Volume 7171, Multimodal Biomedical Imaging IV; 71710U (2009) https://doi.org/10.1117/12.809082
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

The temperature of human body on the surface of the skin depends on the metabolic activity, the blood flow, and the temperature of the surroundings. Any abnormality in the tissue, such as the presence of a tumor, alters the normal temperature on the skin surface due to increased metabolic activity of the tumor. Therefore, abnormal skin temperature profiles are an indication of diseases such as tumor or cancer. This study is to present an approach to detect the female breast tumor and its related parameter estimations by combination the finite element method with infrared thermography for the surface temperature profile. A 2D simplified breast embedded a tumor model based on the female breast anatomical structure and physiological characteristics was first established, and then finite element method was used to analyze the heat diffuse equation for the surface temperature profiles of the breast. The genetic optimization algorithm was used to estimate the tumor parameters such as depth, size and blood perfusion by minimizing a fitness function involving the temperature profiles simulated data by finite element method to the experimental data obtained by infrared thermography. This preliminary study shows it is possible to determine the depth and the heat generation rate of the breast tumor by using infrared thermography and the optimization analysis, which may play an important role in the female breast healthcare and diseases evaluation or early detection. In order to develop the proposed methodology to be used in clinical, more accurate anatomy 3D breast geometry should be considered in further investigations.

Citation Download Citation

A-qing Xu, Hong-qin Yang, Zhen Ye, Yi-ming Su, and Shu-sen Xie "An approach to parameter estimation for breast tumor by finite element method", Proc. SPIE 7171, Multimodal Biomedical Imaging IV, 71710U (20 February 2009); https://doi.org/10.1117/12.809082

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