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We review methods applied to imaging and assessment of the microcirculation and document the
recent progress. Visible and near-infrared light, particularly in the wavelength region of 600 nm
to 1100 nm, offer a window into human and animal tissues due to reduced scattering and
absorption. Laser Doppler perfusion imaging (LDPI) and laser speckle perfusion imaging (LSPI)
are used in the non-invasive investigation of the microcirculation. This paper compares the two
techniques with the recently developed Tissue Viability (TiVi) imaging system, which is
proposed as a useful tool to quantify red blood cell concentration in the microcirculation. Both
imaging and point scanning by the devices were used to quantify microvascular reactivity. The
responses can be explained by physiological understanding and subtle differences by technophysiological
knowledge. The resolution, penetration depth and acquisition rate of each
instrument should be taken into account when choosing a system for a particular clinical
measurement.
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Martin J. Leahy, Neil T. Clancy, Joey G. Enfield, Paul McNamara, Jim O'Doherty, "Recent advances in imaging the microcirculation," Proc. SPIE 7176, Dynamics and Fluctuations in Biomedical Photonics VI, 717602 (12 February 2009); https://doi.org/10.1117/12.808789