Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

The challenges for quantitative photoacoustic imaging

[+] Author Affiliations
B. T. Cox, J. G. Laufer, P. C. Beard

Univ. College London (United Kingdom)

Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 717713 (February 27, 2009); doi:10.1117/12.806788
Text Size: A A A
From Conference Volume 7177

  • Photons Plus Ultrasound: Imaging and Sensing 2009
  • Alexander A. Oraevsky; Lihong V. Wang
  • San Jose, CA | January 24, 2009

abstract

In recent years, some of the promised potential of biomedical photoacoustic imaging has begun to be realised. It has been used to produce good, three-dimensional, images of blood vasculature in mice and other small animals, and in human skin in vivo, to depths of several mm, while maintaining a spatial resolution of <100 μm. Furthermore, photoacoustic imaging depends for contrast on the optical absorption distribution of the tissue under study, so, in the same way that the measurement of optical spectra has traditionally provided a means of determining the molecular constituents of an object, there is hope that multiwavelength photoacoustic imaging will provide a way to distinguish and quantify the component molecules of optically-scattering biological tissue (which may include exogeneous, targeted, chromophores). In simple situations with only a few significant absorbers and some prior knowledge of the geometry of the arrangement, this has been shown to be possible, but significant hurdles remain before the general problem can be solved. The general problem may be stated as follows: is it possible, in general, to take a set of photoacoustic images obtained at multiple optical wavelengths, and process them in a way that results in a set of quantitatively accurate images of the concentration distributions of the constituent chromophores of the imaged tissue? If such an 'inversion' procedure - not specific to any particular situation and free of restrictive suppositions - were designed, then photoacoustic imaging would offer the possibility of high resolution 'molecular' imaging of optically scattering tissue: a very powerful technique that would find uses in many areas of the life sciences and in clinical practice. This paper describes the principal challenges that must be overcome for such a general procedure to be successful.

© (2009) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

B. T. Cox ; J. G. Laufer and P. C. Beard
"The challenges for quantitative photoacoustic imaging", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 717713 (February 27, 2009); doi:10.1117/12.806788; http://dx.doi.org/10.1117/12.806788


Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.