Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo

M. A. Sirotkina; E. V. Zagaynova; M. V. Shirmanova; P. A. Agrba; V. A. Kamensky

doi:10.1117/12.808098

16 February 2009 Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo

M. A. Sirotkina, E. V. Zagaynova, M. V. Shirmanova, P. A. Agrba, V. A. Kamensky

Proceedings Volume 7188, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI; 71880L (2009) https://doi.org/10.1117/12.808098
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Dynamics of nanoparticles penetrating and accumulating in healthy (skin) and pathologically altered (tumor) tissue was investigated in vivo by the method of optical coherence tomography (OCT). Gold nanoshells having the size of 130/15 nm and titanium dioxide nanoparticles 40-100 nm in size were studied. Nanoparticles accumulation in biotissue was accompanied by the change of optical effects in OCT images. Continuous OCT monitoring of the process of nanoparticles penetration into skin showed that optical effects appeared 30 minutes after application of nanoparticles on the surface; maximal effect of nanoparticles accumulation in the skin was recorded in the observation period of 1.5-5 hours. Nanoparticles accumulation in neoplastic tissue at passive delivery was studied in vivo. Accumulation maximum was 4-6 hours after intravenous introduction. The transmission electron microscopy technique confirmed accumulation of nanoparticles in biotissues.

Citation Download Citation

M. A. Sirotkina, E. V. Zagaynova, M. V. Shirmanova, P. A. Agrba, and V. A. Kamensky "Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo", Proc. SPIE 7188, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI, 71880L (16 February 2009); https://doi.org/10.1117/12.808098

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