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Proceedings Article

Two-photon-induced photoluminescence imaging of gold nanoshell's tumor biodistribution

[+] Author Affiliations
Jaesook Park, Arnold Estrada, Andrew K. Dunn, James W. Tunnell

The Univ. of Texas at Austin (USA)

Jon A. Schwartz, Chris Coleman, J. Donald Payne

Nanospectra Biosciences, Inc. (USA)

Parmeswaran Diagaradjane, Sunil Krishnan

The Univ. of Texas M. D. Anderson Cancer Ctr. (USA)

Proc. SPIE 7192, Plasmonics in Biology and Medicine VI, 71920T (February 17, 2009); doi:10.1117/12.809620
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From Conference Volume 7192

  • Plasmonics in Biology and Medicine VI
  • Tuan Vo-Dinh; Joseph R. Lakowicz
  • San Jose, CA | January 24, 2009

abstract

Given their tunable optical properties and high optical absorption and scattering cross sections, gold nanoshells (GNS) have been explored for a number of in vitro and in vivo imaging contrast and cancer therapy agents. While it has been shown that GNSs preferentially accumulate at the tumor site, little is known about the accumulation kinetics within the tumor. We demonstrate accumulation kinetics of GNSs in bulk tumors and histology slides using two-photon induced photoluminescence (TPIP) imaging. We found that GNSs had a heterogeneous distribution with higher accumulation at the tumor cortex. In addition, GNSs were observed in unique patterns surrounding the perivascular region. These results demonstrate that direct luminescence based imaging of metal nanoparticles provides high resolution and molecular specific multiplexed images.

© (2009) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Jaesook Park ; Arnold Estrada ; Jon A. Schwartz ; Parmeswaran Diagaradjane ; Sunil Krishnan, et al.
"Two-photon-induced photoluminescence imaging of gold nanoshell's tumor biodistribution", Proc. SPIE 7192, Plasmonics in Biology and Medicine VI, 71920T (February 17, 2009); doi:10.1117/12.809620; http://dx.doi.org/10.1117/12.809620


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