Application of an image-guided navigation system in breast cancer localization

Tanja Alderliesten; Claudette Loo; Angelique T. E. F. Schlief; Anita Paape; Michiel van der Meer; Kenneth G. A. Gilhuijs

doi:10.1117/12.811121

13 March 2009 Application of an image-guided navigation system in breast cancer localization

Tanja Alderliesten, Claudette Loo, Angelique T. E. F. Schlief, Anita Paape, Michiel van der Meer, Kenneth G. A. Gilhuijs

Author Affiliations +

Proceedings Volume 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling; 726111 (2009) https://doi.org/10.1117/12.811121
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Image-guided navigation on the basis of pre-therapy images in a deformable organ, such as the breast, requires a survey of the factors that cause uncertainties. A deformable breast-tissue-mimicking phantom with simulated tumors was employed to investigate the accuracy of lesion localization with a needle instrument coupled to an optical measurement system. The RMS deviation was 1.1 mm with errors ≤ 2.0 mm in 96% of the procedures. Ultrasonography data acquired during needle localization of breast tumors were analyzed in 20 patients (23 tumors; 12 benign, 11 malignant) to investigate the deformation due to presence of instruments. The overall RMS tumor shift was 2.3 mm after release of pressure on the needle. To establish an optimal strategy to correct for breast motion due to breathing experiments with a volunteer were performed. Tracking a single centre marker was found to be most effective to improve registration accuracy. Average deviations of 8.2 mm were reduced to 1.1 mm. The combined impact of these different uncertainties resulted in distributions defined by: μ = 2.5 mm, σ = 1.4 mm (benign and malignant), μ = 3.1 mm, σ = 1.8 mm (benign), μ = 1.7 mm, σ = 0.9 mm (malignant).

Citation Download Citation

Tanja Alderliesten, Claudette Loo, Angelique T. E. F. Schlief, Anita Paape, Michiel van der Meer, and Kenneth G. A. Gilhuijs "Application of an image-guided navigation system in breast cancer localization", Proc. SPIE 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling, 726111 (13 March 2009); https://doi.org/10.1117/12.811121

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